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Structure paper

TitleX-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex.
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 82, Page 507-522, Year 1995
Publish dateAug 21, 1996 (structure data deposition date)
AuthorsGriffith, J.P. / Kim, J.L. / Kim, E.E. / Sintchak, M.D. / Thomson, J.A. / Fitzgibbon, M.J. / Fleming, M.A. / Caron, P.R. / Hsiao, K. / Navia, M.A.
External linksCell(Cambridge,Mass. ) / PubMed:7543369
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1tco:
TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-FE:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-CA:
Unknown entry

ChemComp-MYR:
MYRISTIC ACID

ChemComp-FK5:
8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN / medication*YM

ChemComp-HOH:
WATER

Source
  • bos taurus (cattle)
KeywordsCOMPLEX (HYDROLASE/ISOMERASE) / COMPLEX (HYDROLASE-ISOMERASE) / IMMUNOSUPPRESSANT / COMPLEX (HYDROLASE-ISOMERASE) complex

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