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TitleChemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 11, Page 747-755, Year 2004
Publish dateMay 11, 2004 (structure data deposition date)
AuthorsPeterson, J.R. / Bickford, L.C. / Morgan, D. / Kim, A.S. / Ouerfelli, O. / Kirschner, M.W. / Rosen, M.K.
External linksNat. Struct. Mol. Biol. / PubMed:15235593
MethodsNMR (solution)
Structure data

PDB-1t84:
Solution structure of the Wiskott-Aldrich Syndrome Protein (WASP) autoinhibited core domain complexed with (S)-wiskostatin, a small molecule inhibitor
Method: SOLUTION NMR

Chemicals

ChemComp-WSK:
(2S)-1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / ALPHA HELIX / BETA-HAIRPIN TURN

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