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Title | A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo. |
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Journal, issue, pages | J. Biol. Chem., Vol. 280, Page 18001-18007, Year 2005 |
Publish date | Apr 23, 2004 (structure data deposition date) |
Authors | de Garavilla, L. / Greco, M.N. / Sukumar, N. / Chen, Z.W. / Pineda, A.O. / Mathews, F.S. / Di Cera, E. / Giardino, E.C. / Wells, G.I. / Haertlein, B.J. ...de Garavilla, L. / Greco, M.N. / Sukumar, N. / Chen, Z.W. / Pineda, A.O. / Mathews, F.S. / Di Cera, E. / Giardino, E.C. / Wells, G.I. / Haertlein, B.J. / Kauffman, J.A. / Corcoran, T.W. / Derian, C.K. / Eckardt, A.J. / Damiano, B.P. / Andrade-Gordon, P. / Maryanoff, B.E. |
External links | J. Biol. Chem. / PubMed:15741158 |
Methods | X-ray diffraction |
Resolution | 1.85 - 1.9 Å |
Structure data | PDB-1t31: PDB-1t32: |
Chemicals | ChemComp-NAG: ChemComp-SO4: ChemComp-CO: ChemComp-OHH: ChemComp-MES: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / HUMAN CHYMASE / SERINE PROTEINASE / INFLAMMATION INHIBITOR SERINE PROTEASE |