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-Structure paper
Title | Crystallographic Analysis Reveals that Anticancer Clinical Candidate L-778,123 Inhibits Protein Farnesyltransferase and Geranylgeranyltransferase-I by Different Binding Modes. |
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Journal, issue, pages | Biochemistry, Vol. 43, Page 9000-9008, Year 2004 |
Publish date | Jan 22, 2004 (structure data deposition date) |
Authors | Reid, T.S. / Long, S.B. / Beese, L.S. |
External links | Biochemistry / PubMed:15248757 |
Methods | X-ray diffraction |
Resolution | 1.9 - 2.55 Å |
Structure data | PDB-1s63: PDB-1s64: |
Chemicals | ChemComp-ZN: ChemComp-FPP: ChemComp-778: ChemComp-HOH: ChemComp-SO4: ChemComp-MES: ChemComp-CL: |
Source |
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Keywords | TRANSFERASE / FARNESYLTRANSFERASE / FTASE / GERANYLGERANYLTRANSFERASE / CANCER / CAAX / FTI / INHIBITOR / RAS / LIPID MODIFICATION / PROTEIN PRENYLATION / L-778 / 123 / protein geranylgeranyltransferase type-I / drug |