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Structure paper

TitleThree-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs
Journal, issue, pagesProteins, Vol. 42, Page 182-191, Year 2001
Publish dateJun 28, 1999 (structure data deposition date)
AuthorsBartolucci, C. / Perola, E. / Pilger, C. / Fels, G. / Lamba, D.
External linksProteins / PubMed:11119642
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1qti:
Acetylcholinesterase (E.C.3.1.1.7)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-GNT:
(-)-GALANTHAMINE / inhibitor, alkaloid*YM

ChemComp-HOH:
WATER

Source
  • torpedo californica (Pacific electric ray)
KeywordsHYDROLASE / ALZHEIMER'S DISEASE / DRUG / SERINE HYDROLASE / ALPHA/BETA HYDROLASE / NEUROTRANSMITTER CLEAVEAGE / CATALYTIC TRIAD

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