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TitleComparison of Kifunensine and 1-Deoxymannojirimycin Binding to Class I and II alpha-Mannosidases Demonstrates Different Saccharide Distortions in Inverting and Retaining Catalytic Mechanisms
Journal, issue, pagesBiochemistry, Vol. 42, Page 13812-13816, Year 2003
Publish dateJun 20, 2003 (structure data deposition date)
AuthorsShah, N. / Kuntz, D.A. / Rose, D.R.
External linksBiochemistry / PubMed:14636047
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-1ps3:
Golgi alpha-mannosidase II in complex with kifunensine
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-ZN:
Unknown entry

ChemComp-KIF:
KIFUNENSINE / inhibitor, alkaloid*YM

ChemComp-MRD:
(4R)-2-METHYLPENTANE-2,4-DIOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • drosophila melanogaster (fruit fly)
KeywordsHYDROLASE / glycosyl hydrolase / mannosidase / N-TERMINAL ALPHA-BETA DOMAIN / THREE HELIX BUNDLE / 2 C-TERMINAL BETA BARRELS

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