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TitleThe 1.14 a crystal structure of yeast Cytosine deaminase. Evolution of nucleotide salvage enzymes and implications for genetic chemotherapy.
Journal, issue, pagesStructure, Vol. 11, Page 961-972, Year 2003
Publish dateApr 1, 2003 (structure data deposition date)
AuthorsIreton, G.C. / Black, M.E. / Stoddard, B.L.
External linksStructure / PubMed:12906827
MethodsX-ray diffraction
Resolution1.14 - 1.43 Å
Structure data

PDB-1ox7:
Crystal structure of yeast cytosine deaminase apo-enzyme: inorganic zinc bound
Method: X-RAY DIFFRACTION / Resolution: 1.43 Å

PDB-1p6o:
The crystal structure of yeast cytosine deaminase bound to 4(R)-hydroxyl-3,4-dihydropyrimidine at 1.14 angstroms.
Method: X-RAY DIFFRACTION / Resolution: 1.14 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-HPY:
4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE

ChemComp-ACY:
ACETIC ACID

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsHYDROLASE / aminohydrolase / cytosine deaminase / dimer / inhibitor bound

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