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Structure paper

TitleStructural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
Journal, issue, pagesMol. Cell, Vol. 11, Page 951-, Year 2003
Publish dateJan 30, 2003 (structure data deposition date)
AuthorsLincecum, T. / Tukalo, M. / Yaremchuk, A. / Mursinna, R. / Williams, A. / Sproat, B. / Van Den Eynde, W. / Link, A. / Van Calenbergh, S. / Grotli, M. ...Lincecum, T. / Tukalo, M. / Yaremchuk, A. / Mursinna, R. / Williams, A. / Sproat, B. / Van Den Eynde, W. / Link, A. / Van Calenbergh, S. / Grotli, M. / Martinis, S. / Cusack, S.
External linksMol. Cell / PubMed:12718881
MethodsX-ray diffraction
Resolution2.1 - 2.2 Å
Structure data

PDB-1obc:
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A POST-TRANSFER EDITING SUBSTRATE ANALOGUE
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-1obh:
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A PRE-TRANSFER EDITING SUBSTRATE ANALOGUE IN BOTH SYNTHETIC ACTIVE SITE AND EDITING SITE
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-LEU:
LEUCINE

ChemComp-ZN:
Unknown entry

ChemComp-NVA:
NORVALINE

ChemComp-2AD:
2'-AMINO-2'-DEOXYADENOSINE

ChemComp-LMS:
[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-HG:
Unknown entry

Source
  • thermus thermophilus (bacteria)
KeywordsSYNTHETASE / AMINOACYL-TRNA SYNTHETASE / CLASS I AMINOACYL-TRNA SYNTHETASE / ATP + L-LEUCINE + TRNA (LEU) -> AMP + PPI L-LEUCYL-TRNA(LEU) / ATP + L-LEUCINE + TRNA (LEU) -> AMP + PPI L- LEUCYL-TRNA(LEU)

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