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TitleNovel and Selective Imidazole-containing Biphenyl Inhibitors of Protein Farnesyltransferase
Journal, issue, pagesBIOORG. MED. CHEM. LETT., Vol. 13, Page 1367-1371, Year 2003
Publish dateJan 6, 2003 (structure data deposition date)
AuthorsCurtin, M.L. / Florjancic, A.S. / Cohen, J. / Gu, W.-J. / Frost, D.J. / Muchmore, S.W. / Sham, H.L.
External linksBIOORG. MED. CHEM. LETT. / PubMed:12657284
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-1nl4:
Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HFP:
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID

ChemComp-FTL:
4-[(3-CYANO-BENZYL)-(3-METHYL-3H-IMIDAZOL-4-YLMETHYL)-AMINO]-2-NAPHTHALEN-1-YL-BENZONITRILE

Source
  • rattus norvegicus (Norway rat)
KeywordsTRANSFERASE / Prenyltransferase

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