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Structure paper

TitleNovel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum.
Journal, issue, pagesJ. Mol. Biol., Vol. 327, Page 173-181, Year 2003
Publish dateApr 10, 2002 (structure data deposition date)
AuthorsAsojo, O.A. / Gulnik, S.V. / Afonina, E. / Yu, B. / Ellman, J.A. / Haque, T.S. / Silva, A.M.
External linksJ. Mol. Biol. / PubMed:12614616
MethodsX-ray diffraction
Resolution1.9 - 2.8 Å
Structure data

PDB-1lf3:
CRYSTAL STRUCTURE OF PLASMEPSIN II FROM P FALCIPARUM IN COMPLEX WITH INHIBITOR EH58
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-1lf4:
STRUCTURE OF PLASMEPSIN II
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-1ls5:
Crystal structure of plasmepsin IV from P. falciparum in complex with pepstatin A
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-EH5:
N-(1-BENZYL-3-{[3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONYL]-[2-(HEXAHYDRO-BENZO[1,3]DIOXOL-5-YL)-ETHYL]-AMINO}-2-HYDROXY-PROPYL)-4-BENZYLOXY-3,5-DIMETHOXY-BENZAMIDE

ChemComp-HOH:
WATER

Source
  • plasmodium falciparum (malaria parasite P. falciparum)
  • streptomyces argenteolus subsp. toyonakensis (bacteria)
KeywordsHYDROLASE / plasmepsin / plasmodium falciparum / aspartic protease / HYDROLASE/HYDROLASE INHIBITOR / EUKARYOTIC ASPARTIC PROTEINASE / HYDROLASE-HYDROLASE INHIBITOR complex

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