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TitleThe structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates.
Journal, issue, pagesBiochemistry, Vol. 41, Page 9043-9051, Year 2002
Publish dateMay 10, 2002 (structure data deposition date)
AuthorsAsante-Appiah, E. / Patel, S. / Dufresne, C. / Roy, P. / Wang, Q. / Patel, V. / Friesen, R.W. / Ramachandran, C. / Becker, J.W. / Leblanc, Y. ...Asante-Appiah, E. / Patel, S. / Dufresne, C. / Roy, P. / Wang, Q. / Patel, V. / Friesen, R.W. / Ramachandran, C. / Becker, J.W. / Leblanc, Y. / Kennedy, B.P. / Scapin, G.
External linksBiochemistry / PubMed:12119018
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1lqf:
Structure of PTP1b in Complex with a Peptidic Bisphosphonate Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-BGD:
N-BENZOYL-L-GLUTAMYL-[4-PHOSPHONO(DIFLUOROMETHYL)]-L-PHENYLALANINE-[4-PHOSPHONO(DIFLUORO-METHYL)]-L-PHENYLALANINEAMIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Phosphatase / phosphonates / diabetes / inhibitor

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