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TitleCrystal Structure of the Ternary Complex of the Catalytic Domain of Human Phenylalanine Hydroxylase with Tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its Implications for the Mechanism of Catalysis and Substrate Activation
Journal, issue, pagesJ. Mol. Biol., Vol. 320, Page 1095-1108, Year 2002
Publish dateJan 28, 2002 (structure data deposition date)
AuthorsAndersen, O.A. / Flatmark, T. / Hough, E.
External linksJ. Mol. Biol. / PubMed:12126628
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1kw0:
Catalytic Domain of Human Phenylalanine Hydroxylase (Fe(II)) in Complex with Tetrahydrobiopterin and Thienylalanine
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-FE2:
Unknown entry

ChemComp-H4B:
5,6,7,8-TETRAHYDROBIOPTERIN / neurotransmitter*YM

ChemComp-TIH:
BETA(2-THIENYL)ALANINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Basket-arrangement 13 alpha-helices and 6 beta-strands / Ferrous iron

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