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TitleNon-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
Journal, issue, pagesJ. Mol. Biol., Vol. 315, Page 103-111, Year 2002
Publish dateMay 15, 2001 (structure data deposition date)
AuthorsWeiss, M.A. / Wan, Z. / Zhao, M. / Chu, Y.C. / Nakagawa, S.H. / Burke, G.T. / Jia, W. / Hellmich, R. / Katsoyannis, P.G.
External linksJ. Mol. Biol. / PubMed:11779231
MethodsX-ray diffraction
Resolution2 - 2.5 Å
Structure data

PDB-1j73:
Crystal structure of an unstable insulin analog with native activity.
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1jca:
Non-standard Design of Unstable Insulin Analogues with Enhanced Activity
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

KeywordsHORMONE/GROWTH FACTOR / A8-Diaminobutyric Acid human insulin / hormone-receptor interface / HORMONE-GROWTH FACTOR COMPLEX / A8-Lysine human insulin / insulin receptor

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