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Structure paper

TitleStructure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
Journal, issue, pagesEMBO J., Vol. 20, Page 3008-3017, Year 2001
Publish dateJan 2, 2001 (structure data deposition date)
Authorsvan den Elsen, J.M. / Kuntz, D.A. / Rose, D.R.
External linksEMBO J. / PubMed:11406577
MethodsX-ray diffraction
Resolution1.4 - 1.87 Å
Structure data

PDB-1hty:
GOLGI ALPHA-MANNOSIDASE II
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-1hww:
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SWAINSONINE
Method: X-RAY DIFFRACTION / Resolution: 1.87 Å

PDB-1hxk:
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH DEOXYMANNOJIRIMICIN
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-ZN:
Unknown entry

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-MRD:
(4R)-2-METHYLPENTANE-2,4-DIOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-SWA:
1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL / chemotherapy, inhibitor, alkaloid*YM

ChemComp-DMJ:
1-DEOXYMANNOJIRIMYCIN

Source
  • drosophila melanogaster (fruit fly)
KeywordsHYDROLASE / N-terminal alpha-beta domain / three helix bundle / 2 C-terminal beta barrels

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