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TitleStructural Basis of Phospholipase A2 Inhibition for the Synthesis of Prostaglandins by the Plant Alkaloid Aristolochic Acid from a 1.7 A Crystal Structure
Journal, issue, pagesBiochemistry, Vol. 41, Page 10914-10919, Year 2002
Publish dateSep 18, 2000 (structure data deposition date)
AuthorsChandra, V. / Jasti, J. / Kaur, P. / Srinivasan, A. / Betzel, C. / Singh, T.P.
External linksBiochemistry / PubMed:12206661
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-1fv0:
FIRST STRUCTURAL EVIDENCE OF THE INHIBITION OF PHOSPHOLIPASE A2 BY ARISTOLOCHIC ACID: CRYSTAL STRUCTURE OF A COMPLEX FORMED BETWEEN PHOSPHOLIPASE A2 AND ARISTOLOCHIC ACID
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-ACT:
ACETATE ION

ChemComp-9AR:
9-HYDROXY ARISTOLOCHIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-DIO:
1,4-DIETHYLENE DIOXIDE

ChemComp-HOH:
WATER

Source
  • daboia russellii pulchella (snake)
KeywordsTOXIN / phospholipase A2 / Daboia russelli pulchella / neurotoxic / edema

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