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TitleStructural mechanism for STI-571 inhibition of abelson tyrosine kinase.
Journal, issue, pagesScience, Vol. 289, Page 1938-1942, Year 2000
Publish dateAug 31, 2000 (structure data deposition date)
AuthorsSchindler, T. / Bornmann, W. / Pellicena, P. / Miller, W.T. / Clarkson, B. / Kuriyan, J.
External linksScience / PubMed:10988075
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-1fpu:
CRYSTAL STRUCTURE OF ABL KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-PRC:
N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-3-PYRIDINECARBOXAMIDE

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsTRANSFERASE / kinase / kinase inhibitor / STI-571 / activation loop

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