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Structure paper

TitleStructural and kinetic analysis of drug resistant mutants of HIV-1 protease.
Journal, issue, pagesEur. J. Biochem., Vol. 263, Page 238-245, Year 1999
Publish dateNov 1, 1999 (structure data deposition date)
AuthorsMahalingam, B. / Louis, J.M. / Reed, C.C. / Adomat, J.M. / Krouse, J. / Wang, Y.F. / Harrison, R.W. / Weber, I.T.
External linksEur. J. Biochem. / PubMed:10429209
MethodsX-ray diffraction
Resolution1.55 - 2.06 Å
Structure data

PDB-1daz:
Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-1dw6:
Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

PDB-1ebk:
Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

Chemicals

ChemComp-0Q4:
N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
KeywordsHYDROLASE/HYDROLASE INHIBITOR / HIV-1 PROTEASE / HYDROLASE-HYDROLASE INHIBITOR COMPLEX / REDUCED PEPTIDE INHIBITOR

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