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-Structure paper
Title | Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs. |
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Journal, issue, pages | J. Mol. Biol., Vol. 295, Page 307-323, Year 2000 |
Publish date | Nov 17, 1999 (structure data deposition date) |
![]() | Li, R. / Sirawaraporn, R. / Chitnumsub, P. / Sirawaraporn, W. / Wooden, J. / Athappilly, F. / Turley, S. / Hol, W.G. |
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Methods | X-ray diffraction |
Resolution | 1.7 - 2 Å |
Structure data | ![]() PDB-1df7: ![]() PDB-1dg5: ![]() PDB-1dg7: ![]() PDB-1dg8: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-NDP: ![]() ChemComp-MTX: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-TOP: ![]() ChemComp-WRB: |
Source |
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![]() | OXIDOREDUCTASE / DIHYDROFOLATE REDUCTASE / STRUCTURE-BASED INHIBITOR DESIGN / FOLATEANALOGS / ROSSMANN FOLD / NICOTINAMIDE ADENINE DINUCLEOTIDE / METHOTREXATE / TUBERCULOSIS / TRIMETHOPRIM / WR99210 / ANTI-MALARIA AGENT |