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Structure paper

TitleStructures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Journal, issue, pagesNature, Vol. 401, Page 188-193, Year 1999
Publish dateJul 28, 1999 (structure data deposition date)
AuthorsFinnin, M.S. / Donigian, J.R. / Cohen, A. / Richon, V.M. / Rifkind, R.A. / Marks, P.A. / Breslow, R. / Pavletich, N.P.
External linksNature / PubMed:10490031
MethodsX-ray diffraction
Resolution1.8 - 2.5 Å
Structure data

PDB-1c3p:
CRYSTAL STRUCTURE OF AN HDAC HOMOLOG FROM AQUIFEX AEOLICUS
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1c3r:
CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH TRICHOSTATIN A
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1c3s:
CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH SAHA
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

ChemComp-TSN:
TRICHOSTATIN A / antifungal, antibiotic*YM

ChemComp-SHH:
OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE

Source
  • aquifex aeolicus (bacteria)
KeywordsLYASE / ALPHA/BETA FOLD / HYDROXAMIC ACID / CHARGE-RELAY SYSTEM / PENTA-COORDINATED ZINC

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