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Structure paper

TitleStructural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Journal, issue, pagesBiochemistry, Vol. 37, Page 17773-17783, Year 1998
Publish dateOct 27, 1998 (structure data deposition date)
AuthorsGroves, M.R. / Yao, Z.J. / Roller, P.P. / Burke Jr., T.R. / Barford, D.
External linksBiochemistry / PubMed:9922143
MethodsX-ray diffraction
Resolution2.1 - 2.35 Å
Structure data

PDB-1bzc:
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-1bzh:
Cyclic peptide inhibitor of human PTP1B
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-1bzj:
Human ptp1b complexed with tpicooh
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-TPI:
4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID

ChemComp-HOH:
WATER

ChemComp-PIC:
6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID

Source
  • homo sapiens (human)
KeywordsHYDROLASE / HYDROLASE(PHOSPHORYLATION) / TYROSINE PHOSPHATASE / INHIBITOR COMPLEX / HYDROLASE/HYDROLASE INHIBITOR / PHOSPHORYLATION-INHIBITOR COMPLEX / HYDROLASE-HYDROLASE INHIBITOR complex / PHOSPHORYLATION / PROTEIN TYROSINE PHOSPHATASE

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