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Structure paper

TitleStrategy for modular assembly of tetravalent, multispecific antibodies.
Journal, issue, pagesProtein Sci., Vol. 35, Page e70797-e70797, Year 2026
Publish dateMay 1, 2026 (structure data deposition date)
AuthorsMallette, E. / Blazer, L.L. / Hokanson, C.A. / Chen, C. / Perez, J.G. / Pavlenco, A. / Ploder, L. / Singer, A.U. / Suits, M.D.L. / Bhakta, S. ...Mallette, E. / Blazer, L.L. / Hokanson, C.A. / Chen, C. / Perez, J.G. / Pavlenco, A. / Ploder, L. / Singer, A.U. / Suits, M.D.L. / Bhakta, S. / Junutula, J.R. / Adams, J.J. / Sidhu, S.S.
External linksProtein Sci. / PubMed:42757708
MethodsX-ray diffraction
Resolution1.64 - 2.22 Å
Structure data

PDB-13ds:
Structure of FabS1CE2_P3a in complex with the N-terminal domain of PD-L1
Method: X-RAY DIFFRACTION / Resolution: 1.93 Å

PDB-13dt:
Structure of FabS1CE2_P4a in complex with the N-terminal domain of PD-L1
Method: X-RAY DIFFRACTION / Resolution: 1.64 Å

PDB-13fl:
Structure of FabS1CE2_P2a in complex with the N-terminal domain of PD-L1
Method: X-RAY DIFFRACTION / Resolution: 2.22 Å

PDB-13ha:
The structure of Fab_C1 in complex with CD30
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-NA:
Unknown entry

ChemComp-CIT:
CITRIC ACID

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / high-affinity binding / immune suppression / tumour growth suppressor / cell signalling / PD-L1 / cytokine receptor

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