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Title structure of the Dot/Icm type IV secretion system by electron cryotomography.
Journal, issue, pagesEMBO Rep, Vol. 18, Issue 5, Page 726-732, Year 2017
Publish dateMar 23, 2017
AuthorsDebnath Ghosal / Yi-Wei Chang / Kwangcheol C Jeong / Joseph P Vogel / Grant J Jensen /
PubMed AbstractType IV secretion systems (T4SSs) are large macromolecular machines that translocate protein and DNA and are involved in the pathogenesis of multiple human diseases. Here, using electron ...Type IV secretion systems (T4SSs) are large macromolecular machines that translocate protein and DNA and are involved in the pathogenesis of multiple human diseases. Here, using electron cryotomography (ECT), we report the structure of the Dot/Icm type IVB secretion system (T4BSS) utilized by the human pathogen This is the first structure of a type IVB secretion system, and also the first structure of any T4SS While the Dot/Icm system shares almost no sequence similarity with type IVA secretion systems (T4ASSs), its overall structure is seen here to be remarkably similar to previously reported T4ASS structures (those encoded by the R388 plasmid in and the cag pathogenicity island in ). This structural similarity suggests shared aspects of mechanism. However, compared to the negative-stain reconstruction of the purified T4ASS from the R388 plasmid, the Dot/Icm system is approximately twice as long and wide and exhibits several additional large densities, reflecting type-specific elaborations and potentially better structural preservation .
External linksEMBO Rep / PubMed:28336774 / PubMed Central
MethodsEM (subtomogram averaging)
Resolution30.0 Å
Structure data

EMDB-8566:
In vivo structure of the Legionella pneumophila Dot/Icm type IV secretion system (aligning the outer membrane complex)
Method: EM (subtomogram averaging) / Resolution: 30.0 Å

EMDB-8567:
In vivo structure of the Legionella pneumophila Dot/Icm type IV secretion system (aligning the inner membrane complex)
Method: EM (subtomogram averaging) / Resolution: 30.0 Å

EMDB-8568:
In vivo structure of the Legionella pneumophila Dot/Icm type IV secretion system core complex (aligning the outer membrane complex)
Method: EM (subtomogram averaging) / Resolution: 30.0 Å

EMDB-8569:
In vivo structure of the Legionella pneumophila Dot/Icm type IV secretion system core complex (aligning the inner membrane part)
Method: EM (subtomogram averaging) / Resolution: 30.0 Å

Source
  • Legionella pneumophila (bacteria)

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