Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Mechanistic and antigenic boundaries of Henipavirus and Parahenipavirus glycoproteins.
Journal, issue, pages	Nat Commun, Year 2026
Publish date	Jun 19, 2026
Authors	Aaron J May / Muralikrishna Lella / Jared Lindenberger / Alex Berkman / Ujjwal Kumar / Kejun Liu / Moumita Dutta / Maggie Barr / Rob Parks / Xiaozhi Lu / Madison Berry / Amanda Powell / Amelia G Thompson / Sravya Sowdamini Nakka / Camila T França / Xiao Huang / Arpita Mrigwani / Kijun Song / Victor Ilevbare / Salam Sammour / Chan Soo Park / Radha Devkota Adhikari / Priyanka Devkota / Katarzyna Janowska / Yanshun Liu / Garrett Scapellato / Taylor N Spence / Katayoun Mansouri / Kevin Wiehe / Nancy J Sullivan / Rosemarie Mason / Robert J Edwards / Kevin O Saunders / Barton F Haynes / Priyamvada Acharya /
PubMed Abstract	Henipaviruses, in the Paramyxoviridae family, includes the highly virulent Nipah virus that causes reoccurring outbreaks of deadly disease. Recent discoveries of Henipavirus-like species, including ...Henipaviruses, in the Paramyxoviridae family, includes the highly virulent Nipah virus that causes reoccurring outbreaks of deadly disease. Recent discoveries of Henipavirus-like species, including the zoonotic Langya virus, have revealed much higher antigenic diversity than currently characterized and prompted the reorganization of these viruses into the Henipavirus and Parahenipavirus genera. Here, to explore the limits of structural and antigenic variation in both genera, collectively referred to as HNVs, we construct an expanded, diverse panel of HNV fusion and attachment glycoproteins from non-redundant HNV strains that better reflect global HNV diversity. We express and purify the fusion protein ectodomains and the attachment protein head domains and study their biochemical and biophysical properties. We perform immunization experiments in mice, eliciting antibodies reactive to multiple HNV fusion proteins. Cryo-electron microscopy structures elucidate molecular determinants of differential pre-fusion state stability and higher order contacts. A crystal structure of the Gamak virus attachment head domain reveals an additional domain appended to the conserved 6-bladed, β-propeller fold. Taken together, these studies expand the known structural and antigenic limits of the HNVs, reveal cross-reactive epitopes within both genera and provide foundational data for the development of broadly reactive countermeasures.
External links	Nat Commun / PubMed:42321170
Methods	EM (single particle) / X-ray diffraction
Resolution	1.42 - 7.39 Å
Structure data	48423 9mnh EMDB-48423, PDB-9mnh: Angavokely virus (AngV) fusion (F) protein ectodomain in pre-fusion conformation Method: EM (single particle) / Resolution: 4.03 Å 48535 9mqn EMDB-48535, PDB-9mqn: AngV-F Pre-fusion Protein Method: EM (single particle) / Resolution: 5.9 Å 48715 9nz0 EMDB-48715: Cryo-EM map of vaccine elicited antibody 22F5 bound to post-fusion conformation of Langya virus F protein PDB-9nz0: Cryo-EM structure of vaccine elicited antibody 22F5 bound to the post-fusion conformation of the LayV-F glycoprotein Method: EM (single particle) / Resolution: 3.31 Å 49948 9nz2 EMDB-49948, PDB-9nz2: Cryo-EM structure of antibody 22F5 in complex with pre-fusion stabilized LayV-F Method: EM (single particle) / Resolution: 4.46 Å EMDB entry, No image EMDB-76165: Nipah virus fusion protein with 20G7 antibody fab Method: EM (single particle) / Resolution: 5.07 Å EMDB entry, No image EMDB-76168: Nipah virus fusion protein ectodomain in complex with 8C7 antibody fab Method: EM (single particle) / Resolution: 5.27 Å EMDB entry, No image EMDB-76170: Hendra virus fusion protein ectodomain in complex with 9A9 antibody fab Method: EM (single particle) / Resolution: 7.39 Å PDB-9ehu: Crystal structure of the Gamak virus attachment protein head domain Method: X-RAY DIFFRACTION / Resolution: 1.42 Å
Chemicals	ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose ChemComp-GOL: GLYCEROL ChemComp-SO4: SULFATE ION ChemComp-MG: Unknown entry ChemComp-HOH: WATER
Source	angavokely henipavirus langya virus mus musculus (house mouse) Homo sapiens (human) parahenipavirus
Keywords	VIRAL PROTEIN / fusion / glycoprotein / virus / Henipavirus / AngV-F protein / Pre-fusion F protein / Cryo-EM structure / Fusion Ectodomain / Dimer-of-trimer / IMMUNE SYSTEM/VIRAL PROTEIN / Langya virus / vaccine-elicited antibody / DII domain / shrew-origin / ANTIVIRAL PROTEIN / IMMUNE SYSTEM-VIRAL PROTEIN complex / parahenipavirus / cross-reactive