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TitleActivation of the angiotensin II type I receptor by a non-peptide agonist
Journal, issue, pagesTo Be Published
Publish dateJan 3, 2026 (structure data deposition date)
AuthorsSkiba MA / Liu J / Shen P / Kim J / Wren E / Gilman MSA / Staus D / McMahon C / Smith JS / Lefkowitz RJ ...Skiba MA / Liu J / Shen P / Kim J / Wren E / Gilman MSA / Staus D / McMahon C / Smith JS / Lefkowitz RJ / Kahne D / Wingler LM / Kruse AC
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.2 - 3.4 Å
Structure data

74919

9zxc

EMDB-74919, PDB-9zxc:
Structure of AT118-R nanobody in complex with the angiotensin II type I receptor bound to losartan
Method: EM (single particle) / Resolution: 3.4 Å

74920

9zxd

EMDB-74920, PDB-9zxd:
Structure of AT118-R nanobody in complex with the angiotensin II type I receptor bound to L-162,313
Method: EM (single particle) / Resolution: 3.2 Å

Chemicals

ChemComp-Y01:
CHOLESTEROL HEMISUCCINATE

ChemComp-LSN:
[2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol

PDB-1c42:
Unknown entry

Source
  • homo sapiens (human)
  • synthetic construct (others)
  • escherichia coli (E. coli)
KeywordsMEMBRANE PROTEIN / GPCR / nanobody

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