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TitleAntigenic and EM characterization of the Chiron experimental hepatitis C virus vaccine.
Journal, issue, pagesVaccine, Vol. 58, Page 127239, Year 2025
Publish dateJun 11, 2025
AuthorsShr-Hau Hung / Jonathan L Torres / Fang Chen / Erick Giang / Andrew B Ward / Mansun Law /
PubMed AbstractThe Chiron experimental HCV vaccine, the only envelope-based HCV vaccine candidate to date, was immunogenic and safe in a phase 1 trial, though its efficacy remains untested. This study examined the ...The Chiron experimental HCV vaccine, the only envelope-based HCV vaccine candidate to date, was immunogenic and safe in a phase 1 trial, though its efficacy remains untested. This study examined the antigenic properties of the vaccine antigens by immunoassays and EM, revealing inconsistent presentation of AR1/5 epitopes. The vaccine elicited mainly strain-specific neutralizing antibodies in humans and non-human primates, highlighting the need for rational antigen design to improve vaccine breadth.
External linksVaccine / PubMed:40381513 / PubMed Central
MethodsEM (single particle)
Resolution15.17 Å
Structure data

EMDB-74809: HCV Chiron E1E2 complexed with AR3A and AR4A Fabs
Method: EM (single particle) / Resolution: 15.17 Å

Source
  • Hepacivirus hominis

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