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Structure paper

TitleStructural basis for rosuvastatin-induced activation of skeletal muscle ryanodine receptor 1.
Journal, issue, pagesNat Commun, Vol. 17, Issue 1, Year 2026
Publish dateSep 3, 2026
AuthorsGunnar Weninger / Steven Reiken / Qi Yuan / Marco C Miotto / Alexander Chang / Yang Liu / Anetta Wronska / Haikel Dridi / Andrew R Marks /
PubMed AbstractStatin therapies, used to lower high blood cholesterol, have been proposed to cause skeletal muscle side effects including myalgia and rhabdomyolysis. The ryanodine receptor 1 (RyR1)/Ca²⁺ release ...Statin therapies, used to lower high blood cholesterol, have been proposed to cause skeletal muscle side effects including myalgia and rhabdomyolysis. The ryanodine receptor 1 (RyR1)/Ca²⁺ release channel in skeletal muscle has recently been identified as an off-target binder of statins. Here, we report the cryo-electron microscopy structure of RyR1 in complex with rosuvastatin. Rosuvastatin occupies a single binding site in the pore region of RyR1 stabilizing the open conformation. In the closed conformation, the rosuvastatin binding site is occupied by the RyR1 auxiliary transmembrane helices (TMx1-2). Structural comparison indicates steric overlap of rosuvastatin with simvastatin (at Sim-1) but not with atorvastatin on RyR1, while all these statins may interfere with the conformational stability of the TMx1-2 helices. In contrast to simvastatin and atorvastatin, rosuvastatin does not exhibit multiple binding sites on RyR1 while similarly promoting RyR1 activation, indicating its potential as a preferable lead structure for developing statins that minimizes adverse side effects on RyR1.
External linksNat Commun / PubMed:42830339 / PubMed Central
MethodsEM (single particle)
Resolution2.41 - 3.75 Å
Structure data

74471

9zo8

EMDB-74471, PDB-9zo8:
Structure of RyR1 in presence of rosuvastatin (including auxiliary transmembrane helices TMx1 and TMx2; Ca2+/CFF/ATP dataset; closed pore)
Method: EM (single particle) / Resolution: 2.7 Å

EMDB-74472: Raw consensus map of RyR1 in presence of rosuvastatin (including auxiliary transmembrane helices TMx1 and TMx2; Ca2+/CFF/ATP dataset; closed pore)
Method: EM (single particle) / Resolution: 2.7 Å

EMDB-74473: Constituent EM map: Focused refinement on NTD/SPRY/Calstabin-1 of RyR1 in presence of rosuvastatin (including auxiliary transmembrane helices TMx1 and TMx2; Ca2+/CFF/ATP dataset; closed pore)
Method: EM (single particle) / Resolution: 2.8 Å

EMDB-74474: Constituent EM map: Focused refinement on JSol/CSol of RyR1 in presence of rosuvastatin (including auxiliary transmembrane helices TMx1 and TMx2; Ca2+/CFF/ATP dataset; closed pore)
Method: EM (single particle) / Resolution: 2.82 Å

EMDB-74477: Constituent EM map: Focused refinement on BSol of RyR1 in presence of rosuvastatin (including auxiliary transmembrane helices TMx1 and TMx2; Ca2+/CFF/ATP dataset; closed pore)
Method: EM (single particle) / Resolution: 3.28 Å

EMDB-74478: Constituent EM map: Focused refinement on TaF/TMD/CTD of RyR1 in presence of rosuvastatin (including auxiliary transmembrane helices TMx1 and TMx2; Ca2+/CFF/ATP dataset; closed pore)
Method: EM (single particle) / Resolution: 2.5 Å

EMDB-74479: Constituent EM map: Focused refinement on Ry12 of RyR1 in presence of rosuvastatin (including auxiliary transmembrane helices TMx1 and TMx2; Ca2+/CFF/ATP dataset; closed pore)
Method: EM (single particle) / Resolution: 3.46 Å

EMDB-74480: Constituent EM map: Focused refinement on Ry34 of RyR1 in presence of rosuvastatin (including auxiliary transmembrane helices TMx1 and TMx2; Ca2+/CFF/ATP dataset; closed pore)
Method: EM (single particle) / Resolution: 3.75 Å

EMDB-74482: Constituent EM map: Focused refinement on TMx region of RyR1 in presence of rosuvastatin (including auxiliary transmembrane helices TMx1 and TMx2; Ca2+/CFF/ATP dataset; closed pore)
Method: EM (single particle) / Resolution: 2.52 Å

EMDB-74484: Raw consensus map of RyR1 in presence of rosuvastatin (Ca2+/CFF/ATP dataset; closed pore)
Method: EM (single particle) / Resolution: 2.59 Å

74486

9zoe

EMDB-74486, PDB-9zoe:
Structure of RyR1 in complex with rosuvastatin (Ca2+/CFF/ATP dataset; open pore)
Method: EM (single particle) / Resolution: 2.9 Å

EMDB-74487: Raw consensus map of RyR1 in complex with rosuvastatin (Ca2+/CFF/ATP dataset; open pore)
Method: EM (single particle) / Resolution: 2.86 Å

EMDB-74488: Constituent EM map: Focused refinement on NTD/SPRY/Calstabin-1 of RyR1 in complex with rosuvastatin (Ca2+/CFF/ATP dataset; open pore)
Method: EM (single particle) / Resolution: 2.51 Å

EMDB-74489: Constituent EM map: Focused refinement on JSol/CSol of RyR1 in complex with rosuvastatin (Ca2+/CFF/ATP dataset; open pore)
Method: EM (single particle) / Resolution: 2.49 Å

EMDB-74491: Constituent EM map: Focused refinement on BSol of RyR1 in complex with rosuvastatin (Ca2+/CFF/ATP dataset; open pore)
Method: EM (single particle) / Resolution: 2.8 Å

EMDB-74492: Constituent EM map: Focused refinement on TaF/TMD/CTD of RyR1 in complex with rosuvastatin (Ca2+/CFF/ATP dataset; open pore)
Method: EM (single particle) / Resolution: 2.56 Å

EMDB-74493: Constituent EM map: Focused refinement on Ry12 of RyR1 in complex with rosuvastatin (Ca2+/CFF/ATP dataset; open pore)
Method: EM (single particle) / Resolution: 2.79 Å

EMDB-74494: Constituent EM map: Focused refinement on Ry34 of RyR1 in complex with rosuvastatin (Ca2+/CFF/ATP dataset; open pore)
Method: EM (single particle) / Resolution: 2.89 Å

EMDB-74495: Constituent EM map: Focused refinement on TMx region of RyR1 in complex with rosuvastatin (Ca2+/CFF/ATP dataset; open pore)
Method: EM (single particle) / Resolution: 2.41 Å

Chemicals

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-CA:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-CFF:
CAFFEINE / medication*YM

ChemComp-PCW:
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE / DOPC, phospholipid*YM

PDB-1c3z:
THP12-CARRIER PROTEIN FROM YELLOW MEAL WORM

Source
  • oryctolagus cuniculus (rabbit)
KeywordsTRANSPORT PROTEIN / Calcium / Ion Channel / Membrane Protein

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