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Structure paper

TitleConformational cycling of the Wntless transporter drives trafficking and secretion of Wnt morphogens
Journal, issue, pagesTo Be Published
Publish dateNov 10, 2025 (structure data deposition date)
AuthorsGe Y / de Almeida Magalhaes T / Wu H / van den Boomen DJH / Nguyen TU / Dou T / Yadav GP / Lee S / Wang Z / Lemoff A ...Ge Y / de Almeida Magalhaes T / Wu H / van den Boomen DJH / Nguyen TU / Dou T / Yadav GP / Lee S / Wang Z / Lemoff A / Luo X / Jin Z / Jiang J / Salic A / Huang P
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.63 - 3.38 Å
Structure data

EMDB-73803: Cryo-EM structure of human Wntless in complex with Wnt5a at 1:1 stoichiometry
Method: EM (single particle) / Resolution: 2.64 Å

EMDB-73810: Cryo-EM structure of human Wntless in its apo state
Method: EM (single particle) / Resolution: 2.63 Å

EMDB-73835: Cryo-EM structure of human Wntless-Wnt5a 2:2 complex - Focused map A
Method: EM (single particle) / Resolution: 3.38 Å

EMDB-73836: Cryo-EM structure of human Wntless-Wnt5a 2:2 complex - Focused map B
Method: EM (single particle) / Resolution: 3.25 Å

EMDB-73837: Cryo-EM structure of human Wntless-Wnt5a 2:2 complex - Consensus map
Method: EM (single particle) / Resolution: 3.32 Å

EMDB-73838: Cryo-EM structure of human Wntless-Wnt5a 2:2 complex - Composite map
Method: EM (single particle) / Resolution: 3.32 Å

Source
  • Homo sapiens (human)

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