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Structure paper

TitleTumor suppressors BCDX2-CX3 supercomplex and DX2-CX3 complex template RAD51 filament formation
Journal, issue, pagesTo Be Published
Publish dateAug 14, 2025 (structure data deposition date)
AuthorsKoo CW / Ciferri C / Yatskevich S
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.49 - 3.24 Å
Structure data

72148

9q23

EMDB-72148, PDB-9q23:
DX2-CX3-RAD51 structure in the intermediate state
Method: EM (single particle) / Resolution: 2.84 Å

72150

9q25

EMDB-72150, PDB-9q25:
DX2-CX3-RAD51 in the closed state
Method: EM (single particle) / Resolution: 3.24 Å

72152

9q28

EMDB-72152, PDB-9q28:
DX2-CX3-RAD51 in the active state
Method: EM (single particle) / Resolution: 2.84 Å

72153

9q29

EMDB-72153, PDB-9q29:
DX2-CX3 structure capping RAD51 filament
Method: EM (single particle) / Resolution: 2.61 Å

72154

9q2a

EMDB-72154, PDB-9q2a:
BCDX2-CX3-RAD51-RAD51-ssDNA supercomplex
Method: EM (single particle) / Resolution: 2.67 Å

72155

9q2b

EMDB-72155, PDB-9q2b:
DX2-CX3-RAD51 bound to DNA bubble
Method: EM (single particle) / Resolution: 3.2 Å

EMDB-72227: Composite map of DX2-CX3 bound to RAD51 filament
Method: EM (single particle) / Resolution: 2.61 Å

EMDB-72230: Composite map of BCDX2-CX3-RAD51 complex
Method: EM (single particle) / Resolution: 2.7 Å

EMDB-72231: Local refinement of RAD51-RAD51 body of BCDX2-CX3-RAD51 complex
Method: EM (single particle) / Resolution: 2.68 Å

EMDB-72232: Local refinement of CX3 body of BCDX2-CX3-RAD51 complex
Method: EM (single particle) / Resolution: 2.57 Å

EMDB-72233: Local refinement of BCDX2 body of BCDX2-CX3-RAD51 complex
Method: EM (single particle) / Resolution: 2.66 Å

EMDB-72234: Local refinement of XRCC3-RAD51-RAD51 body of DX2-CX3 bound to RAD51 filament
Method: EM (single particle) / Resolution: 2.49 Å

EMDB-72235: Local refinement of RAD51 filament body of DX2-CX3 bound to RAD51 filament
Method: EM (single particle) / Resolution: 2.54 Å

EMDB-72236: Local refinement of CDX2 body of DX2-CX3-RAD51 filament, unsharpened map
Method: EM (single particle) / Resolution: 2.72 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-CA:
Unknown entry

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsDNA BINDING PROTEIN/DNA / RAD51 paralog / DX2-CX3 complex / DNA BINDING PROTEIN / DNA BINDING PROTEIN-DNA complex

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