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TitleRegulation of purine synthesis and chemotherapy response by metabolite-derived molecular glues
Journal, issue, pagesTo Be Published
Publish dateAug 13, 2025 (structure data deposition date)
AuthorsWitus SRW / Kober MM / Roh H / Yang Z / Choueiry F / Ghate AS / Titov DV / Rape M
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.8 - 3.1 Å
Structure data

72099

9q0m

EMDB-72099, PDB-9q0m:
Cryo-EM structure of PPAT-NUDT5 complex bound to adenosine-5'-monophosphate (AMP)
Method: EM (single particle) / Resolution: 3.1 Å

72100

9q0n

EMDB-72100, PDB-9q0n:
Cryo-EM structure of PPAT-NUDT5 complex bound to 6-methylthioinosine-5'-monophosphate (6-meTIMP)
Method: EM (single particle) / Resolution: 2.8 Å

72101

9q0o

EMDB-72101, PDB-9q0o:
Cryo-EM structure of PPAT-NUDT5 complex bound to 6-benzylthioinosine-5'-monophosphate (6-benzylTIMP)
Method: EM (single particle) / Resolution: 2.9 Å

Chemicals

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-MG:
Unknown entry

PDB-1cq3:
STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS

PDB-1cq4:
CI2 MUTANT WITH TETRAGLUTAMINE (MGQQQQGM) REPLACING MET59

Source
  • homo sapiens (human)
KeywordsBIOSYNTHETIC PROTEIN / Complex / Purine synthesis / phosphoribosyltransferase

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