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TitleEnd Processing in NHEJ by Polymerase lambda and PNKP is coordinated during short-range synapsis
Journal, issue, pagesTo Be Published
Publish dateJun 3, 2025 (structure data deposition date)
AuthorsVogt A / Kaminski AM / Pedersen LC / Naila T / Tomkinson AE / Lees-Miller SP / Kunkel TA / He Y
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.86 - 7.23 Å
Structure data

EMDB-70949: Distal Ku-Polymerase lambda BRCT
Method: EM (single particle) / Resolution: 3.86 Å

EMDB-70957: XRCC4-XLF Scafoold
Method: EM (single particle) / Resolution: 4.58 Å

EMDB-70958: NHEJ Short-range Pol lambda complex (consensus map)
Method: EM (single particle) / Resolution: 7.23 Å

EMDB-70959: Proximal Ku-LigIV catalytic domain-Pol lambda BRCT
Method: EM (single particle) / Resolution: 4.43 Å

70960

9ox8

EMDB-70960, PDB-9ox8:
NHEJ Short-range complex with Polymerase lambda
Method: EM (single particle) / Resolution: 7.23 Å

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN/DNA / DNA repair / NHEJ / Complex / Polymerase / DNA BINDING PROTEIN / DNA BINDING PROTEIN-DNA complex

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