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TitleCryo-EM structure of human PRMT5:MEP50 in complex with SAH and compounds 16-19F and HJL-1
Journal, issue, pagesTo Be Published
Publish dateJun 1, 2025 (structure data deposition date)
AuthorsXu X / Chi Z / Jiang W / Li C
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.1 Å
Structure data

70926

9ovy

EMDB-70926, PDB-9ovy:
Cryo-EM structure of human PRMT5:MEP50 in complex with SAH and compounds 16-19F and HJL-1
Method: EM (single particle) / Resolution: 3.1 Å

Chemicals

ChemComp-65B:
4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

PDB-1ceu:
NMR STRUCTURE OF THE (1-51) N-TERMINAL DOMAIN OF THE HIV-1 REGULATORY PROTEIN

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / arginine methyltransferase

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