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TitleCereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry
Journal, issue, pagesNat. Struct. Mol. Biol., Year 2026
Publish dateMay 23, 2025 (structure data deposition date)
AuthorsAnnunziato S / Quan C / Donckele EJ / Lamberto I / Bunker RD / Zlotosch M / Schwander L / Murthy A / Wiedmer L / Staehly C ...Annunziato S / Quan C / Donckele EJ / Lamberto I / Bunker RD / Zlotosch M / Schwander L / Murthy A / Wiedmer L / Staehly C / Matysik M / Gilberto S / Kapsitidou D / Wible D / de Donatis GD / Trenh P / SriRamaratnam R / Strande V / Almeida R / Dolgikh E / DeMarco B / Tsai J / Sadok A / Zarayskiy V / Walter M / Tiedt R / Lumb KJ / Bonenfant D / Fasching B / Castle JC / Townson SA / Petzold G / Gainza P
External linksNat. Struct. Mol. Biol. / Search PubMed
MethodsEM (single particle)
Resolution2.5 Å
Structure data

70791

9os2

EMDB-70791, PDB-9os2:
Cryo-EM structure of the DDB1/CRBN-MRT-5702-G3BP2 ternary complex
Method: EM (single particle) / Resolution: 2.5 Å

Chemicals

ChemComp-ZN:
Unknown entry

PDB-1ced:
THE STRUCTURE OF CYTOCHROME C6 FROM MONORAPHIDIUM BRAUNII, NMR, MINIMIZED AVERAGE STRUCTURE

Source
  • homo sapiens (human)
KeywordsLIGASE / molecular glue degrader / neo-substrate / cereblon / E3 ubiquitin ligase

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