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Structure paper

TitleMechanisms of human mitochondrial leaderless mRNA translation initiation
Journal, issue, pagesNat Commun, Year 2026
Publish dateMay 7, 2025 (structure data deposition date)
AuthorsShen S / Xu Y / Kober DL / Wang J
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.5 - 3.01 Å
Structure data

EMDB-70533: Human 28S in complex with mtIF2 and mtIF3
Method: EM (single particle) / Resolution: 3.01 Å

70544

9ojm

EMDB-70544, PDB-9ojm:
Human mitochondrial 28S PIC with tRNA and mtIF2
Method: EM (single particle) / Resolution: 2.5 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-ZN:
Unknown entry

ChemComp-FES:
FE2/S2 (INORGANIC) CLUSTER

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsRIBOSOME / Mitochondrial Ribosome 28S pre-initiation complex

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