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- EMDB-70544: Human mitochondrial 28S PIC with tRNA and mtIF2 -

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Basic information

Entry
Database: EMDB / ID: EMD-70544
TitleHuman mitochondrial 28S PIC with tRNA and mtIF2
Map datahuman 28S PIC
Sample
  • Complex: Human mitochondrial 28S PIC with tRNA and mtIF2
    • Protein or peptide: x 31 types
    • RNA: x 3 types
  • Ligand: x 8 types
KeywordsMitochondrial Ribosome 28S pre-initiation complex / RIBOSOME
Function / homology
Function and homology information


mitochondrial translational initiation / translation factor activity, RNA binding / mitochondrial ribosome assembly / Mitochondrial translation elongation / Mitochondrial translation initiation / Mitochondrial ribosome-associated quality control / Mitochondrial translation termination / negative regulation of mitotic nuclear division / mitochondrial ribosome / ribosome disassembly ...mitochondrial translational initiation / translation factor activity, RNA binding / mitochondrial ribosome assembly / Mitochondrial translation elongation / Mitochondrial translation initiation / Mitochondrial ribosome-associated quality control / Mitochondrial translation termination / negative regulation of mitotic nuclear division / mitochondrial ribosome / ribosome disassembly / mitochondrial small ribosomal subunit / regulation of translational initiation / mitochondrial translation / positive regulation of proteolysis / apoptotic mitochondrial changes / ribosomal small subunit binding / translation initiation factor activity / Mitochondrial protein degradation / apoptotic signaling pathway / fibrillar center / regulation of translation / small ribosomal subunit / small ribosomal subunit rRNA binding / nuclear membrane / intracellular membrane-bounded organelle / Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement / tRNA binding / cell population proliferation / mitochondrial inner membrane / rRNA binding / structural constituent of ribosome / ribosome / translation / mitochondrial matrix / GTPase activity / mRNA binding / GTP binding / nucleolus / mitochondrion / RNA binding / nucleoplasm / nucleus / plasma membrane / cytoplasm / cytosol
Similarity search - Function
Translation initiation factor IF-2, domain II / Initiation factor 2 signature. / Translation initiation factor IF-2, bacterial-like / : / Elongation factor G domain 2 / Translation initiation factor IF- 2, domain 3 / Translation-initiation factor 2 / Translation initiation factor IF- 2 / Translation initiation factor IF-2, domain 3 superfamily / Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 ...Translation initiation factor IF-2, domain II / Initiation factor 2 signature. / Translation initiation factor IF-2, bacterial-like / : / Elongation factor G domain 2 / Translation initiation factor IF- 2, domain 3 / Translation-initiation factor 2 / Translation initiation factor IF- 2 / Translation initiation factor IF-2, domain 3 superfamily / Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 / Cysteine alpha-hairpin motif superfamily / 28S ribosomal protein S26 / Mitochondrial ribosome subunit S26 / 28S ribosomal protein S27, mitochondrial / MRPS27/PTCD2 / Mitochondrial 28S ribosomal protein S27 / Ribosomal protein S22, mitochondrial / : / Mitochondrial 28S ribosomal protein S22 / Ribosomal protein S29, mitochondrial / Ribosomal protein S28, mitochondrial / 28S ribosomal protein S10, mitochondrial / Mitochondrial ribosomal protein MRP-S35 / 28S ribosomal protein S24, mitochondrial / Mitochondrial 28S ribosomal protein S34 / Pentatricopeptide repeat domain-containing protein 3 / 28S ribosomal protein S17, mitochondrial / : / : / Mitochondrial ribosome subunit S24 / Mitochondrial 28S ribosomal protein S34 / Small ribosomal subunit protein uS5m, N-terminal / Small ribosomal subunit protein mS39, PPR / 28S ribosomal protein S25, mitochondrial / Pentatricopeptide repeat domain / Ribosomal protein S27/S33, mitochondrial / Ribosomal protein S24/S35, mitochondrial / Mitochondrial ribosomal subunit S27 / Ribosomal protein S24/S35, mitochondrial, conserved domain / Mitochondrial ribosomal subunit protein / Pentatricopeptide (PPR) repeat profile. / Pentatricopeptide repeat / Ribosomal protein S23/S29, mitochondrial / Mitochondrial ribosomal death-associated protein 3 / Mitochondrial mRNA-processing protein COX24, C-terminal / Mitochondrial mRNA-processing protein COX24, C-terminal / Mitochondrial domain of unknown function (DUF1713) / CHCH / CHCH domain / Coiled coil-helix-coiled coil-helix (CHCH) domain profile. / Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain / Ribosomal protein/NADH dehydrogenase domain / Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain / Ribosomal protein S21 superfamily / Translational (tr)-type GTP-binding domain / Elongation factor Tu GTP binding domain / Translational (tr)-type guanine nucleotide-binding (G) domain profile. / Ribosomal protein S21 / Ribosomal protein S21 / Ribosomal protein S2, bacteria/mitochondria/plastid / Ribosomal protein S9, bacterial/plastid / Ribosomal protein S16 / Ribosomal protein S16 domain superfamily / Ribosomal protein S16 / Ribosomal protein S15, bacterial-type / Ribosomal protein S6 / Ribosomal protein S6 / Ribosomal protein S6 superfamily / Ribosomal protein S12, bacterial-type / Translation elongation factor EF1B/ribosomal protein S6 / Ribosomal protein S2 signature 1. / Small GTP-binding protein domain / Ribosomal protein S5, N-terminal, conserved site / Ribosomal protein S5 signature. / Ribosomal protein S2, conserved site / Ribosomal protein S2 / Ribosomal protein S2, flavodoxin-like domain superfamily / Ribosomal protein S2 / Ribosomal protein S5 / S5 double stranded RNA-binding domain profile. / Ribosomal protein S5, N-terminal / Ribosomal protein S5, C-terminal / Ribosomal protein S5, N-terminal domain / Ribosomal protein S5, C-terminal domain / Ribosomal protein S14 / Ribosomal protein S14p/S29e / Tetratricopeptide-like helical domain superfamily / Ribosomal protein S10p/S20e / Ribosomal S11, conserved site / Ribosomal protein S11 signature. / Ribosomal protein S10 domain / Ribosomal protein S10 domain superfamily / Ribosomal protein S10p/S20e / Ribosomal protein S11 / Ribosomal protein S9, conserved site / Ribosomal protein S9 signature. / Ribosomal protein S12 signature. / Ribosomal protein S11 / Ribosomal protein S5/S7 / Ribosomal protein S7 domain
Similarity search - Domain/homology
Small ribosomal subunit protein uS12m / Small ribosomal subunit protein uS14m / Translation initiation factor IF-2, mitochondrial / Small ribosomal subunit protein mS29 / Small ribosomal subunit protein mS22 / Small ribosomal subunit protein mS25 / Small ribosomal subunit protein uS10m / Small ribosomal subunit protein mS35 / Small ribosomal subunit protein uS5m / Small ribosomal subunit protein uS11m ...Small ribosomal subunit protein uS12m / Small ribosomal subunit protein uS14m / Translation initiation factor IF-2, mitochondrial / Small ribosomal subunit protein mS29 / Small ribosomal subunit protein mS22 / Small ribosomal subunit protein mS25 / Small ribosomal subunit protein uS10m / Small ribosomal subunit protein mS35 / Small ribosomal subunit protein uS5m / Small ribosomal subunit protein uS11m / Small ribosomal subunit protein uS15m / Small ribosomal subunit protein bS21m / Small ribosomal subunit protein mS34 / Small ribosomal subunit protein bS6m / Small ribosomal subunit protein uS9m / Small ribosomal subunit protein mS27 / Small ribosomal subunit protein mS37 / Small ribosomal subunit protein uS3m / Small ribosomal subunit protein mS39 / Small ribosomal subunit protein mS26 / Small ribosomal subunit protein mS38 / Small ribosomal subunit protein mS33 / Small ribosomal subunit protein bS1m / Small ribosomal subunit protein uS17m / Small ribosomal subunit protein uS7m / Small ribosomal subunit protein uS2m / Small ribosomal subunit protein bS16m
Similarity search - Component
Biological speciesHomo sapiens (human)
Methodsingle particle reconstruction / cryo EM / Resolution: 2.5 Å
AuthorsKober DL / Wang J
Funding support United States, 4 items
OrganizationGrant numberCountry
Welch FoundationI-2218-20240404 United States
Welch FoundationI-2246-20250403 United States
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)R00GM141261 United States
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)R01GM155152 United States
CitationJournal: Nat Commun / Year: 2026
Title: Mechanisms of human mitochondrial leaderless mRNA translation initiation
Authors: Shen S / Xu Y / Kober DL / Wang J
History
DepositionMay 8, 2025-
Header (metadata) releaseMar 18, 2026-
Map releaseMar 18, 2026-
UpdateMar 18, 2026-
Current statusMar 18, 2026Processing site: RCSB / Status: Released

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Structure visualization

Supplemental images

emd_70544.png

Downloads & links

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Map

FileDownload / File: emd_70544.map.gz / Format: CCP4 / Size: 824 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
Annotationhuman 28S PIC
Projections & slices

Image control

Size
Brightness
Contrast
Others
AxesZ (Sec.)Y (Row.)X (Col.)
0.83 Å/pix.
x 600 pix.
= 495.6 Å		0.83 Å/pix.
x 600 pix.
= 495.6 Å		0.83 Å/pix.
x 600 pix.
= 495.6 Å

Surface

Projections

Slices (1/3)

Slices (1/2)

Slices (2/3)

Images are generated by Spider.

Voxel sizeX=Y=Z: 0.826 Å
Density

Histogram

Histogram (log scale)
Contour LevelBy AUTHOR: 0.028
Minimum - Maximum-0.12213263 - 0.39145038
Average (Standard dev.)-0.000047256413 (±0.007458203)
SymmetrySpace group: 1
Details

EMDB XML:

Map geometry
Axis orderXYZ
Origin000
Dimensions600600600
Spacing600600600
CellA=B=C: 495.59998 Å
α=β=γ: 90.0 °

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Supplemental data

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Half map: half map A

Fileemd_70544_half_map_1.map
Annotationhalf map A
Projections & Slices
AxesZYX

Projections

Slices (1/2)
Density Histograms

Histogram

Histogram (log scale)

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Half map: half map B

Fileemd_70544_half_map_2.map
Annotationhalf map B
Projections & Slices
AxesZYX

Projections

Slices (1/2)
Density Histograms

Histogram

Histogram (log scale)

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Sample components

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Entire : Human mitochondrial 28S PIC with tRNA and mtIF2

EntireName: Human mitochondrial 28S PIC with tRNA and mtIF2
Components
  • Complex: Human mitochondrial 28S PIC with tRNA and mtIF2
    • Protein or peptide: Small ribosomal subunit protein mS34
    • Protein or peptide: Small ribosomal subunit protein mS35
    • Protein or peptide: Coiled-coil-helix-coiled-coil-helix domain-containing protein 1
    • Protein or peptide: Small ribosomal subunit protein mS38
    • Protein or peptide: Small ribosomal subunit protein mS39
    • RNA: RNA (71-MER)
    • RNA: mRNA (5'-R(P*AP*UP*GP*U)-3')
    • Protein or peptide: Translation initiation factor IF-2, mitochondrial
    • RNA: 12S mitochondrial RNA
    • Protein or peptide: Small ribosomal subunit protein uS2m
    • Protein or peptide: 28S ribosomal protein S24, mitochondrial
    • Protein or peptide: 28S ribosomal protein S5, mitochondrial
    • Protein or peptide: 28S ribosomal protein S6, mitochondrial
    • Protein or peptide: 28S ribosomal protein S7, mitochondrial
    • Protein or peptide: Small ribosomal subunit protein uS9m
    • Protein or peptide: Small ribosomal subunit protein uS10m
    • Protein or peptide: Small ribosomal subunit protein uS11m
    • Protein or peptide: 28S ribosomal protein S12, mitochondrial
    • Protein or peptide: 28S ribosomal protein S14, mitochondrial
    • Protein or peptide: Small ribosomal subunit protein uS15m
    • Protein or peptide: Small ribosomal subunit protein bS16m
    • Protein or peptide: Small ribosomal subunit protein uS17m
    • Protein or peptide: 28S ribosomal protein S18b, mitochondrial
    • Protein or peptide: 28S ribosomal protein S18c, mitochondrial
    • Protein or peptide: 28S ribosomal protein S21, mitochondrial
    • Protein or peptide: Small ribosomal subunit protein mS22
    • Protein or peptide: 28S ribosomal protein S23, mitochondrial
    • Protein or peptide: Small ribosomal subunit protein mS25
    • Protein or peptide: Small ribosomal subunit protein mS26
    • Protein or peptide: Small ribosomal subunit protein mS27
    • Protein or peptide: Small ribosomal subunit protein bS1m
    • Protein or peptide: Small ribosomal subunit protein mS29
    • Protein or peptide: 28S ribosomal protein S27, mitochondrial
    • Protein or peptide: Small ribosomal subunit protein mS33
  • Ligand: MAGNESIUM ION
  • Ligand: POTASSIUM ION
  • Ligand: GUANOSINE-5'-TRIPHOSPHATE
  • Ligand: ZINC ION
  • Ligand: FE2/S2 (INORGANIC) CLUSTER
  • Ligand: GUANOSINE-5'-DIPHOSPHATE
  • Ligand: ADENOSINE-5'-TRIPHOSPHATE
  • Ligand: water

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Supramolecule #1: Human mitochondrial 28S PIC with tRNA and mtIF2

SupramoleculeName: Human mitochondrial 28S PIC with tRNA and mtIF2 / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#34
Source (natural)Organism: Homo sapiens (human)

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Macromolecule #1: Small ribosomal subunit protein mS34

MacromoleculeName: Small ribosomal subunit protein mS34 / type: protein_or_peptide / ID: 1 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 25.336084 KDa
SequenceString: KKVRPRLIAE LARRVRALRE QLNRPRDSQL YAVDYETLTR PFSGRRLPVR AWADVRRESR LLQLLGRLPL FGLGRLVTRK SWLWQHDEP CYWRLTRVRP DYTAQNLDHG KAWGILTFKG KTESEAREIE HVMYHDWRLV PKHEEEAFTA FTPAPEDSLA S VPYPPLLR ...String:
KKVRPRLIAE LARRVRALRE QLNRPRDSQL YAVDYETLTR PFSGRRLPVR AWADVRRESR LLQLLGRLPL FGLGRLVTRK SWLWQHDEP CYWRLTRVRP DYTAQNLDHG KAWGILTFKG KTESEAREIE HVMYHDWRLV PKHEEEAFTA FTPAPEDSLA S VPYPPLLR AMIIAERQKN GDTSTEEPML NVQRIRMEPW DYPAKQEDKG RAKGTPV

UniProtKB: Small ribosomal subunit protein mS34

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Macromolecule #2: Small ribosomal subunit protein mS35

MacromoleculeName: Small ribosomal subunit protein mS35 / type: protein_or_peptide / ID: 2 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 32.156938 KDa
SequenceString: RPPRRKALPP RTEKMAVDQD WPSVYPVAAP FKPSAVPLPV RMGYPVKKGV PMAKEGNLEL LKIPNFLHLT PVAIKKHCEA LKDFCTEWP AALDSDEKCE KHFPIEIDST DYVSSGPSVR NPRARVVVLR VKLSSLNLDD HAKKKLIKLV GERYCKTTDV L TIKTDRCP ...String:
RPPRRKALPP RTEKMAVDQD WPSVYPVAAP FKPSAVPLPV RMGYPVKKGV PMAKEGNLEL LKIPNFLHLT PVAIKKHCEA LKDFCTEWP AALDSDEKCE KHFPIEIDST DYVSSGPSVR NPRARVVVLR VKLSSLNLDD HAKKKLIKLV GERYCKTTDV L TIKTDRCP LRRQNYDYAV YLLTVLYHES WNTEEWEKSK TEADMEEYIW ENSSSERNIL ETLLQMKAAE KNMEINKEEL LG TKEIEEY KKSVVSLKNE EENENSISQY KESVKRLLNV T

UniProtKB: Small ribosomal subunit protein mS35

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Macromolecule #3: Coiled-coil-helix-coiled-coil-helix domain-containing protein 1

MacromoleculeName: Coiled-coil-helix-coiled-coil-helix domain-containing protein 1
type: protein_or_peptide / ID: 3 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 13.498819 KDa
SequenceString:
MATPSLRGRL ARFGNPRKPV LKPNKPLILA NRVGERRREK GEATCITEMS VMMACWKQNE FRDDACRKEI QGFLDCAARA QEARKMRSI QETLGESGSL LPNKLNKLLQ RFPNKPYLS

UniProtKB: Small ribosomal subunit protein mS37

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Macromolecule #4: Small ribosomal subunit protein mS38

MacromoleculeName: Small ribosomal subunit protein mS38 / type: protein_or_peptide / ID: 4 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 8.936875 KDa
SequenceString:
KNVLKIRRRK MNHHKYRKLV KKTRFLRRKV QEGRLRRKQI KFEKDLRRIW LKAGLKEAPE GWQTPKIYLR G

UniProtKB: Small ribosomal subunit protein mS38

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Macromolecule #5: Small ribosomal subunit protein mS39

MacromoleculeName: Small ribosomal subunit protein mS39 / type: protein_or_peptide / ID: 5 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 70.984156 KDa
SequenceString: EEVVIPKKKT WDKVAVLQAL ASTVNRDTTA VPYVFQDDPY LMPASSLESR SFLLAKKSGE NVAKFIINSY PKYFQKDIAE PHIPCLMPE YFEPQIKDIS EAALKERIEL RKVKASVDMF DQLLQAGTTV SLETTNSLLD LLCYYGDQEP STDYHFQQTG Q SEALEEEN ...String:
EEVVIPKKKT WDKVAVLQAL ASTVNRDTTA VPYVFQDDPY LMPASSLESR SFLLAKKSGE NVAKFIINSY PKYFQKDIAE PHIPCLMPE YFEPQIKDIS EAALKERIEL RKVKASVDMF DQLLQAGTTV SLETTNSLLD LLCYYGDQEP STDYHFQQTG Q SEALEEEN DETSRRKAGH QFGVTWRAKN NAERIFSLMP EKNEHSYCTM IRGMVKHRAY EQALNLYTEL LNNRLHADVY TF NALIEAT VCAINEKFEE KWSKILELLR HMVAQKVKPN LQTFNTILKC LRRFHVFARS PALQVLREMK AIGIEPSLAT YHH IIRLFD QPGDPLKRSS FIIYDIMNEL MGKRFSPKDP DDDKFFQSAM SICSSLRDLE LAYQVHGLLK TGDNWKFIGP DQHR NFYYS KFFDLICLME QIDVTLKWYE DLIPSAYFPH SQTMIHLLQA LDVANRLEVI PKIWKDSKEY GHTFRSDLRE EILML MARD KHPPELQVAF ADCAADIKSA YESQPIRQTA QDWPATSLNC IAILFLRAGR TQEAWKMLGL FRKHNKIPRS ELLNEL MDS AKVSNSPSQA IEVVELASAF SLPICEGLTQ RVMSDFAINQ EQKEALSNLT ALT

UniProtKB: Small ribosomal subunit protein mS39

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Macromolecule #8: Translation initiation factor IF-2, mitochondrial

MacromoleculeName: Translation initiation factor IF-2, mitochondrial / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 63.16918 KDa
SequenceString: DKVRKNKDAV RRPQADPALL TPRSPVVTIM GHVDHGKTTL LDKFRKTQVA AVETGGITQH IGAFLVSLPS GEKITFLDTP GHAAFSAMR ARGAQVTDIV VLVVAADDGV MKQTVESIQH AKDAQVPIIL AVNKCDKAEA DPEKVKKELL AYDVVCEDYG G DVQAVPVS ...String:
DKVRKNKDAV RRPQADPALL TPRSPVVTIM GHVDHGKTTL LDKFRKTQVA AVETGGITQH IGAFLVSLPS GEKITFLDTP GHAAFSAMR ARGAQVTDIV VLVVAADDGV MKQTVESIQH AKDAQVPIIL AVNKCDKAEA DPEKVKKELL AYDVVCEDYG G DVQAVPVS ALTGDNLMAL AEATVALAEM LELKADPNGP VEGTVIESFT DKGRGLVTTA IIQRGTLRKG SVLVAGKCWA KV RLMFDEN GKTIDEAYPS MPVGITGWRD LPSAGEEILE VESEPRAREV VDWRKYEQEQ EKGQEDLKII EEKRKEHKEA HQK AREKYG HLLWKKRSIL RFLERKEQIP LKPKEKRERD SNVLSVIIKG DVDGSVEAIL NIIDTYDASH ECELELVHFG VGDV SANDV NLAETFDGVI YGFNVNAGNV IQQSAAKKGV KIKLHKIIYR LVEDLQEELS SRLPCAVEEH PVGEASILAT FSVTE GKKK VPVAGCRVQK GQLEKQKKFK LTRNGHVIWK GSLTSLKHHK DDISIVKTGM DCGLSLDEDN MEFQVGDRIV CYEEKQ IQA KTSWDPGF

UniProtKB: Translation initiation factor IF-2, mitochondrial

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Macromolecule #10: Small ribosomal subunit protein uS2m

MacromoleculeName: Small ribosomal subunit protein uS2m / type: protein_or_peptide / ID: 10 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 25.988881 KDa
SequenceString: EDSTDFNDKI LNEPLKHSDF FNVKELFSVR SLFDARVHLG HKAGCRHRFM EPYIFGSRLD HDIIDLEQTA THLQLALNFT AHMAYRKGI ILFISRNRQF SYLIENMARD CGEYAHTRYF RGGMLTNARL LFGPTVRLPD LIIFLHTLNN IFEPHVAVRD A AKMNIPTV ...String:
EDSTDFNDKI LNEPLKHSDF FNVKELFSVR SLFDARVHLG HKAGCRHRFM EPYIFGSRLD HDIIDLEQTA THLQLALNFT AHMAYRKGI ILFISRNRQF SYLIENMARD CGEYAHTRYF RGGMLTNARL LFGPTVRLPD LIIFLHTLNN IFEPHVAVRD A AKMNIPTV GIVDTNCNPC LITYPVPGND DSPLAVHLYC RLFQTAITRA KEKRQQVEAL YRLQGQK

UniProtKB: Small ribosomal subunit protein uS2m

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Macromolecule #11: 28S ribosomal protein S24, mitochondrial

MacromoleculeName: 28S ribosomal protein S24, mitochondrial / type: protein_or_peptide / ID: 11 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.333757 KDa
SequenceString:
KNRAARVRVS KGDKPVTYEE AHAPHYIAHR KGWLSLHTGN LDGEDHAAER TVEDVFLRKF MWGTFPGCLA DQLVLKRRGN QLEICAVVL RQLSPHKYYF LVGYSETLLS YFYKCPVRLH LQTVPSKVVY KYL

UniProtKB: Small ribosomal subunit protein uS3m

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Macromolecule #12: 28S ribosomal protein S5, mitochondrial

MacromoleculeName: 28S ribosomal protein S5, mitochondrial / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 38.919043 KDa
SequenceString: SFFTKLTADE LWKGALAETG AGAKKGRGKR TKKKKRKDLN RGQIIGEGRY GFLWPGLNVP LMKNGAVQTI AQRSKEEQEK VEADMIQQR EEWDRKKKMK VKRERGWSGN SWGGISLGPP DPGPCGETYE DFDTRILEVR NVFTMTAKEG RKKSIRVLVA V GNGKGAAG ...String:
SFFTKLTADE LWKGALAETG AGAKKGRGKR TKKKKRKDLN RGQIIGEGRY GFLWPGLNVP LMKNGAVQTI AQRSKEEQEK VEADMIQQR EEWDRKKKMK VKRERGWSGN SWGGISLGPP DPGPCGETYE DFDTRILEVR NVFTMTAKEG RKKSIRVLVA V GNGKGAAG FSIGKATDRM DAFRKAKNRA VHHLHYIERY EDHTIFHDIS LRFKRTHIKM KKQPKGYGLR CHRAIITICR LI GIKDMYA KVSGSINMLS LTQGLFRGLS RQETHQQLAD KKGLHVVEIR EECGPLPIVV ASPRGPLRKD PEPEDEVPDV KLD WEDVKT AQGMKRSVWS NLKRAAT

UniProtKB: Small ribosomal subunit protein uS5m

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Macromolecule #13: 28S ribosomal protein S6, mitochondrial

MacromoleculeName: 28S ribosomal protein S6, mitochondrial / type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 13.861032 KDa
SequenceString:
PRYELALILK AMQRPETAAT LKRTIEALMD RGAIVRDLEN LGERALPYRI SAHSQQHNRG GYFLVDFYAP TAAVESMVEH LSRDIDVIR GNIVKHPLTQ ELKECEGIVP VPLAEKLYST KKR

UniProtKB: Small ribosomal subunit protein bS6m

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Macromolecule #14: 28S ribosomal protein S7, mitochondrial

MacromoleculeName: 28S ribosomal protein S7, mitochondrial / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 24.569783 KDa
SequenceString: SRYSPEFKDP LIDKEYYRKP VEELTEEEKY VRELKKTQLI KAAPAGKTSS VFEDPVISKF TNMMMIGGNK VLARSLMIQT LEAVKRKQF EKYHAASAEE QATIERNPYT IFHQALKNCE PMIGLVPILK GGRFYQVPVP LPDRRRRFLA MKWMITECRD K KHQRTLMP ...String:
SRYSPEFKDP LIDKEYYRKP VEELTEEEKY VRELKKTQLI KAAPAGKTSS VFEDPVISKF TNMMMIGGNK VLARSLMIQT LEAVKRKQF EKYHAASAEE QATIERNPYT IFHQALKNCE PMIGLVPILK GGRFYQVPVP LPDRRRRFLA MKWMITECRD K KHQRTLMP EKLSHKLLEA FHNQGPVIKR KHDLHKMAEA NRALAHYRWW

UniProtKB: Small ribosomal subunit protein uS7m

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Macromolecule #15: Small ribosomal subunit protein uS9m

MacromoleculeName: Small ribosomal subunit protein uS9m / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 40.136102 KDa
SequenceString: AFVIPKKNVP TSKRETYTED FIKKQIEEFN IGKRHLANMM GEDPETFTQE DIDRAIAYLF PSGLFEKRAR PVMKHPEQIF PRQRAIQWG EDGRPFHYLF YTGKQSYYSL MHDVYGMLLN LEKHQSHLQA KSLLPEKTVT RDVIGSRWLI KEELEEMLVE K LSDLDYMQ ...String:
AFVIPKKNVP TSKRETYTED FIKKQIEEFN IGKRHLANMM GEDPETFTQE DIDRAIAYLF PSGLFEKRAR PVMKHPEQIF PRQRAIQWG EDGRPFHYLF YTGKQSYYSL MHDVYGMLLN LEKHQSHLQA KSLLPEKTVT RDVIGSRWLI KEELEEMLVE K LSDLDYMQ FIRLLEKLLT SQCGAAEEEF VQRFRRSVTL ESKKQLIEPV QYDEQGMAFS KSEGKRKTAK AEAIVYKHGS GR IKVNGID YQLYFPITQD REQLMFPFHF VDRLGKHDVT CTVSGGGRSA QAGAIRLAMA KALCSFVTED EVEWMRQAGL LTT DPRVRE RKKPGQEGAR RKFTWKKR

UniProtKB: Small ribosomal subunit protein uS9m

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Macromolecule #16: Small ribosomal subunit protein uS10m

MacromoleculeName: Small ribosomal subunit protein uS10m / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 16.360981 KDa
SequenceString:
LHVDVPKDLT KPVVTISDEP DILYKRLSVL VKGHDKAVLD SYEYFAVLAA KELGISIKVH EPPRKIERFT LLQSVHIYKK HRVQYEMRT LYRCLELEHL TGSTADVYLE YIQRNLPEGV AMEVTKTQLE QLPEHIKEPI W

UniProtKB: Small ribosomal subunit protein uS10m

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Macromolecule #17: Small ribosomal subunit protein uS11m

MacromoleculeName: Small ribosomal subunit protein uS11m / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 14.509841 KDa
SequenceString:
TKFSIYPPIP GEESSLRWAG KKFEEIPIAH IKASHNNTQI QVVSASNEPL AFASCGTEGF RNAKKGTGIA AQTAGIAAAA RAKQKGVIH IRVVVKGLGP GRLSAMHGLI MGGLEVISIT DNTPIPHNGC RPRKARKL

UniProtKB: Small ribosomal subunit protein uS11m

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Macromolecule #18: 28S ribosomal protein S12, mitochondrial

MacromoleculeName: 28S ribosomal protein S12, mitochondrial / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 12.013163 KDa
SequenceString:
ATLNQMHRLG PPKRPPRKLG PTEGRPQLKG VVLCTFTRKP KKPNSANRKC CRVRLSTGRE AVCFIPGEGH TLQEHQIVLV EGGRTQDLP GVKLTVVRGK YDCGHVQKK

UniProtKB: Small ribosomal subunit protein uS12m

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Macromolecule #19: 28S ribosomal protein S14, mitochondrial

MacromoleculeName: 28S ribosomal protein S14, mitochondrial / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 12.282349 KDa
SequenceString:
HYVDWRMWRD VKRRKMAYEY ADERLRINSL RKNTILPKIL QDVADEEIAA LPRDSCPVRI RNRCVMTSRP RGVKRRWRLS RIVFRHLAD HGQLSGIQRA TW

UniProtKB: Small ribosomal subunit protein uS14m

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Macromolecule #20: Small ribosomal subunit protein uS15m

MacromoleculeName: Small ribosomal subunit protein uS15m / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 20.729482 KDa
SequenceString:
LDDDPPPSTL LKDYQNVPGI EKVDDVVKRL LSLEMANKKE MLKIKQEQFM KKIVANPEDT RSLEARIIAL SVKIRSYEEH LEKHRKDKA HKRYLLMSID QRKKMLKNLR NTNYDVFEKI CWGLGIEYTF PPLYYRRAHR RFVTKKALCI RVFQETQKLK K RRRALKAA AAAQKQ

UniProtKB: Small ribosomal subunit protein uS15m

+
Macromolecule #21: Small ribosomal subunit protein bS16m

MacromoleculeName: Small ribosomal subunit protein bS16m / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 13.438712 KDa
SequenceString:
KAYRGGHLTI RLALGGCTNR PFYRIVAAHN KCPRDGRFVE QLGSYDPLPN SHGEKLVALN LDRIRHWIGC GAHLSKPMEK LLGLAGFFP LHPMMITNAE RLRRKRAREV LLASQKTDAE

UniProtKB: Small ribosomal subunit protein bS16m

+
Macromolecule #22: Small ribosomal subunit protein uS17m

MacromoleculeName: Small ribosomal subunit protein uS17m / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 12.34965 KDa
SequenceString:
VRSSVHARWI VGKVIGTKMQ KTAKVRVTRL VLDPYLLKYF NKRKTYFAHD ALQQCTVGDI VLLRALPVPR AKHVKHELAE IVFKVGKVI DPVTGKPCAG TTYLESPLSS E

UniProtKB: Small ribosomal subunit protein uS17m

+
Macromolecule #23: 28S ribosomal protein S18b, mitochondrial

MacromoleculeName: 28S ribosomal protein S18b, mitochondrial / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 22.573775 KDa
SequenceString: PISPYKDEPW KYLESEEYQE RYGSRPVWAD YRRNHKGGVP PQRTRKTCIR RNKVVGNPCP ICRDHKLHVD FRNVKLLEQF VCAHTGIIF YAPYTGVCVK QHKRLTQAIQ KARDHGLLIY HIPQVEPRDL DFSTSHGAVS ATPPAPTLVS GDPWYPWYNW K QPPERELS ...String:
PISPYKDEPW KYLESEEYQE RYGSRPVWAD YRRNHKGGVP PQRTRKTCIR RNKVVGNPCP ICRDHKLHVD FRNVKLLEQF VCAHTGIIF YAPYTGVCVK QHKRLTQAIQ KARDHGLLIY HIPQVEPRDL DFSTSHGAVS ATPPAPTLVS GDPWYPWYNW K QPPERELS RLRRLYQGHL QEESGPPPES MPKMP

+
Macromolecule #24: 28S ribosomal protein S18c, mitochondrial

MacromoleculeName: 28S ribosomal protein S18c, mitochondrial / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 11.188229 KDa
SequenceString:
SNEDLPISME NPYKEPLKKC ILCGKHVDYK NVQLLSQFVS PFTGCIYGRH ITGLCGKKQK EITKAIKRAQ IMGFMPVTYK DPAYLKDPK VCNIRYRE

+
Macromolecule #25: 28S ribosomal protein S21, mitochondrial

MacromoleculeName: 28S ribosomal protein S21, mitochondrial / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 10.764652 KDa
SequenceString:
MAKHLKFIAR TVMVQEGNVE SAYRTLNRIL TMDGLIEDIK HRRYYEKPCR RRQRESYERC RRIYNMEMAR KINFLMRKNR ADPWQGC

UniProtKB: Small ribosomal subunit protein bS21m

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Macromolecule #26: Small ribosomal subunit protein mS22

MacromoleculeName: Small ribosomal subunit protein mS22 / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 34.251141 KDa
SequenceString: ETKKPTFMDE EVQSILTKMT GLNLQKTFKP AIQELKPPTY KLMTQAQLEE ATRQAVEAAK VRLKMPPVLE ERVPINDVLA EDKILEGTE TTKYVFTDIS YSIPHRERFI VVREPSGTLR KASWEERDRM IQVYFPKEGR KILTPIIFKE ENLRTMYSQD R HVDVLNLC ...String:
ETKKPTFMDE EVQSILTKMT GLNLQKTFKP AIQELKPPTY KLMTQAQLEE ATRQAVEAAK VRLKMPPVLE ERVPINDVLA EDKILEGTE TTKYVFTDIS YSIPHRERFI VVREPSGTLR KASWEERDRM IQVYFPKEGR KILTPIIFKE ENLRTMYSQD R HVDVLNLC FAQFEPDSTE YIKVHHKTYE DIDKRGKYDL LRSTRYFGGM VWYFVNNKKI DGLLIDQIQR DLIDDATNLV QL YHVLHPD GQSAQGAKDQ AAEGINLIKV FAKTEAQKGA YIELTLQTYQ EALSRHSA

UniProtKB: Small ribosomal subunit protein mS22

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Macromolecule #27: 28S ribosomal protein S23, mitochondrial

MacromoleculeName: 28S ribosomal protein S23, mitochondrial / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.702971 KDa
SequenceString:
AGSRLETVGS IFSRTRDLVR AGVLKEKPLW FDVYDAFPPL REPVFQRPRV RYGKAKAPIQ DIWYHEDRIR AKFYSVYGSG QRAFDLFNP NFKSTCQRFV EKYTELQKLG ETDEEKLFVE TGKALLAEGV ILRRVG

+
Macromolecule #28: Small ribosomal subunit protein mS25

MacromoleculeName: Small ribosomal subunit protein mS25 / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 19.585846 KDa
SequenceString:
PMKGRFPIRR TLQYLSQGNV VFKDSVKVMT VNYNTHGELG EGARKFVFFN IPQIQYKNPW VQIMMFKNMT PSPFLRFYLD SGEQVLVDV ETKSNKEIME HIRKILGKNE ETLREEEEEK KQLSHPANFG PRKYCLRECI CEVEGQVPCP SLVPLPKEMR G KYKAALKA

UniProtKB: Small ribosomal subunit protein mS25

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Macromolecule #29: Small ribosomal subunit protein mS26

MacromoleculeName: Small ribosomal subunit protein mS26 / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 21.183117 KDa
SequenceString:
RKTRHDPLAK SKIERVNMPP AVDPAEFFVL MERYQHYRQT VRALRMEFVS EVQRKVHEAR AGVLAERKAL KDAAEHRELM AWNQAENRR LHELRIARLR QEEREQEQRQ ALEQARKAEE VQAWAQRKER EVLQLQEEVK NFITRENLEA RVEAALDSRK N YNWAITRE GLVVRPQR

UniProtKB: Small ribosomal subunit protein mS26

+
Macromolecule #30: Small ribosomal subunit protein mS27

MacromoleculeName: Small ribosomal subunit protein mS27 / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 43.969762 KDa
SequenceString: LLSSAYVDSH KWEAREKEHY CLADLASLMD KTFERKLPVS SLTISRLIDN ISSREEIDHA EYYLYKFRHS PNCWYLRNWT IHTWIRQCL KYDAQDKALY TLVNKVQYGI FPDNFTFNLL MDSFIKKENY KDALSVVFEV MMQEAFEVPS TQLLSLYVLF H CLAKKTDF ...String:
LLSSAYVDSH KWEAREKEHY CLADLASLMD KTFERKLPVS SLTISRLIDN ISSREEIDHA EYYLYKFRHS PNCWYLRNWT IHTWIRQCL KYDAQDKALY TLVNKVQYGI FPDNFTFNLL MDSFIKKENY KDALSVVFEV MMQEAFEVPS TQLLSLYVLF H CLAKKTDF SWEEERNFGA SLLLPGLKQK NSVGFSSQLY GYALLGKVEL QQGLRAVYHN MPLIWKPGYL DRALQVMEKV AA SPEDIKL CREALDVLGA VLKALTSADG ASEEQSQNDE DNQGSEKLVE QLDIEETEQS KLPQYLERFK ALHSKLQALG KIE SEGLLS LTTQLVKEKL STCEAEDIAT YEQNLQQWHL DLVQLIQREQ QQREQAKQEY QAQ

UniProtKB: Small ribosomal subunit protein mS27

+
Macromolecule #31: Small ribosomal subunit protein bS1m

MacromoleculeName: Small ribosomal subunit protein bS1m / type: protein_or_peptide / ID: 31 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 11.263965 KDa
SequenceString:
NVESFASMLR HSPLTQMGPA KDKLVIGRIF HIVENDLYID FGGKFHCVCR RPEVDGEKYQ KGTRVRLRLL DLELTSRFLG ATTDTTVLE ANAVLLGIQE S

UniProtKB: Small ribosomal subunit protein bS1m

+
Macromolecule #32: Small ribosomal subunit protein mS29

MacromoleculeName: Small ribosomal subunit protein mS29 / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
EC number: Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 40.421258 KDa
SequenceString: AISRTNENDP AKHGDQHEGQ HYNISPQDLE TVFPHGLPPR FVMQVKTFSE ACLMVRKPAL ELLHYLKNTS FAYPAIRYLL YGEKGTGKT LSLCHVIHFC AKQDWLILHI PDAHLWVKNC RDLLQSSYNK QRFDQPLEAS TWLKNFKTTN ERFLNQIKVQ E KYVWNKRE ...String:
AISRTNENDP AKHGDQHEGQ HYNISPQDLE TVFPHGLPPR FVMQVKTFSE ACLMVRKPAL ELLHYLKNTS FAYPAIRYLL YGEKGTGKT LSLCHVIHFC AKQDWLILHI PDAHLWVKNC RDLLQSSYNK QRFDQPLEAS TWLKNFKTTN ERFLNQIKVQ E KYVWNKRE STEKGSPLGE VVEQGITRVR NATDAVGIVL KELKRQSSLG MFHLLVAVDG INALWGRTTL KREDKSPIAP EE LALVHNL RKMMKNDWHG GAIVSALSQT GSLFKPRKAY LPQELLGKEG FDALDPFIPI LVSNYNPKEF ESCIQYYLEN NWL QHEKAP TEEGKKELLF LSNANPSLLE RHCAYL

UniProtKB: Small ribosomal subunit protein mS29

+
Macromolecule #33: 28S ribosomal protein S27, mitochondrial

MacromoleculeName: 28S ribosomal protein S27, mitochondrial / type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 17.631842 KDa
SequenceString:
RKNIFTGKRL NIFDMMAVTK EAPETDTSPS LWDVEFAKQL ATVNEQPLQN GFEELIQWTK EGKLWEFPIN NEAGFDDDGS EFHEHIFLE KHLESFPKQG PIRHFMELVT CGLSKNPYLS VKQKVEHIEW FRNYFNEKKD ILKESNIQFN

+
Macromolecule #34: Small ribosomal subunit protein mS33

MacromoleculeName: Small ribosomal subunit protein mS33 / type: protein_or_peptide / ID: 34 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 11.952871 KDa
SequenceString:
SLSEYAFRMS RLSARLFGEV TRPTNSKSMK VVKLFSELPL AKKKETYDWY PNHHTYAELM QTLRFLGLYR DEHQDFMDEQ KRLKKLRGK EKPKKGEGKR A

UniProtKB: Small ribosomal subunit protein mS33

+
Macromolecule #6: RNA (71-MER)

MacromoleculeName: RNA (71-MER) / type: rna / ID: 6 / Number of copies: 1
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 22.664498 KDa
SequenceString:
AGUAAGGUCA GCUAAAUAAG CUAUCGGGCC CAUACCCCGA AAAUGUUGGU UAUACCCUUC CCGUACUACC A

GENBANK: GENBANK: LC530718.1

+
Macromolecule #7: mRNA (5'-R(P*AP*UP*GP*U)-3')

MacromoleculeName: mRNA (5'-R(P*AP*UP*GP*U)-3') / type: rna / ID: 7 / Number of copies: 1
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 1.241786 KDa
SequenceString:
AUGU

+
Macromolecule #9: 12S mitochondrial RNA

MacromoleculeName: 12S mitochondrial RNA / type: rna / ID: 9 / Number of copies: 1
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 306.547531 KDa
SequenceString: AAUAGGUUUG GUCCUAGCCU UUCUAUUAGC UCUUAGUAAG AUUACACAUG CAAGCAUCCC CGUUCCAGUG AGUUCACCCU CUAAAUCAC CACGAUCAAA AGGGACAAGC AUCAAGCACG CAGCAAUGCA GCUCAAAACG CUUAGCCUAG CCACACCCCC A CGGGAAAC ...String:
AAUAGGUUUG GUCCUAGCCU UUCUAUUAGC UCUUAGUAAG AUUACACAUG CAAGCAUCCC CGUUCCAGUG AGUUCACCCU CUAAAUCAC CACGAUCAAA AGGGACAAGC AUCAAGCACG CAGCAAUGCA GCUCAAAACG CUUAGCCUAG CCACACCCCC A CGGGAAAC AGCAGUGAUU AACCUUUAGC AAUAAACGAA AGUUUAACUA AGCUAUACUA ACCCCAGGGU UGGUCAAUUU CG UGCCAGC CACCGCGGUC ACACGAUUAA CCCAAGUCAA UAGAAGCCGG CGUAAAGAGU GUUUUAGAUC ACCCCCUCCC CAA UAAAGC UAAAACUCAC CUGAGUUGUA AAAAACUCCA GUUGACACAA AAUAGACUAC GAAAGUGGCU UUAACAUAUC UGAA CACAC AAUAGCUAAG ACCCAAACUG GGA(5MU)UAGAUA CCCCACUAUG CUUAGCCCUA AACCUCAACA GUUAAAUCAA C AAAACUGC UCGCCAGAAC ACUACGAGCC ACAGCUUAAA ACUCAAAGGA CCUGGCGGUG CUUCAUAUCC CUCUAGAGGA GC CUGUUCU GUAAUCGAUA AACCCCGAUC AACCUCACCA CCUCUUGCUC AGCCUAUAUA CCGCCAUCUU CAGCAAACCC UGA UGAAGG CUACAAAGUA AGCGCAAGUA CCCACGUAAA GACGUUAGGU CAAGGUGUAG CCCAUGAGGU GGCAAGAAAU GGGC UACAU UUUCUACCCC AGAAAACUAC GAUAGCCCUU AUGAAACUUA AGGGUCGAAG GUGGAUUUAG CAGUAAACUG AGAGU AGAG UGCUUAGUUG AACAGGGCCC UGAAGCGCGU ACACACCG(B8T)C (5MC)GUCACCCUC CUCAAGUAUA CUUCAAAG G ACAUUUAACU AAAACCCCUA CGCAUUUAUA UAGAGGAGAC AAGUCGUAAC AUGGUAAGUG UACUGG(MA6)(MA6)AG U GCACUUGG ACGAACC

GENBANK: GENBANK: MN849517.1

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Macromolecule #35: MAGNESIUM ION

MacromoleculeName: MAGNESIUM ION / type: ligand / ID: 35 / Number of copies: 72 / Formula: MG
Molecular weightTheoretical: 24.305 Da

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Macromolecule #36: POTASSIUM ION

MacromoleculeName: POTASSIUM ION / type: ligand / ID: 36 / Number of copies: 20 / Formula: K
Molecular weightTheoretical: 39.098 Da

+
Macromolecule #37: GUANOSINE-5'-TRIPHOSPHATE

MacromoleculeName: GUANOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 37 / Number of copies: 1 / Formula: GTP
Molecular weightTheoretical: 523.18 Da
Chemical component information

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

+
Macromolecule #38: ZINC ION

MacromoleculeName: ZINC ION / type: ligand / ID: 38 / Number of copies: 1 / Formula: ZN
Molecular weightTheoretical: 65.409 Da

+
Macromolecule #39: FE2/S2 (INORGANIC) CLUSTER

MacromoleculeName: FE2/S2 (INORGANIC) CLUSTER / type: ligand / ID: 39 / Number of copies: 2 / Formula: FES
Molecular weightTheoretical: 175.82 Da
Chemical component information

ChemComp-FES:
FE2/S2 (INORGANIC) CLUSTER

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Macromolecule #40: GUANOSINE-5'-DIPHOSPHATE

MacromoleculeName: GUANOSINE-5'-DIPHOSPHATE / type: ligand / ID: 40 / Number of copies: 1 / Formula: GDP
Molecular weightTheoretical: 443.201 Da
Chemical component information

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

+
Macromolecule #41: ADENOSINE-5'-TRIPHOSPHATE

MacromoleculeName: ADENOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 41 / Number of copies: 1 / Formula: ATP
Molecular weightTheoretical: 507.181 Da
Chemical component information

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

+
Macromolecule #42: water

MacromoleculeName: water / type: ligand / ID: 42 / Number of copies: 1399 / Formula: HOH
Molecular weightTheoretical: 18.015 Da
Chemical component information

ChemComp-HOH:
WATER

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Experimental details

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Structure determination

Methodcryo EM
Processingsingle particle reconstruction
Aggregation stateparticle

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Sample preparation

BufferpH: 7.5
VitrificationCryogen name: ETHANE

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Electron microscopy

MicroscopeTFS KRIOS
Image recordingFilm or detector model: GATAN K3 BIOQUANTUM (6k x 4k) / Average electron dose: 50.0 e/Å2
Electron beamAcceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron opticsIllumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD / Nominal defocus max: 2.5 µm / Nominal defocus min: 1.2 µm
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company

+
Image processing

CTF correctionType: PHASE FLIPPING AND AMPLITUDE CORRECTION
Startup modelType of model: INSILICO MODEL
Final reconstructionResolution.type: BY AUTHOR / Resolution: 2.5 Å / Resolution method: FSC 0.143 CUT-OFF / Software - Name: cryoSPARC (ver. 4.7) / Number images used: 107666
Initial angle assignmentType: MAXIMUM LIKELIHOOD
Final angle assignmentType: MAXIMUM LIKELIHOOD
FSC plot (resolution estimation)

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Atomic model buiding 1

RefinementProtocol: RIGID BODY FIT
Output model

PDB-9ojm:
Human mitochondrial 28S PIC with tRNA and mtIF2

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