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TitleComplementary Structural and Chemical Biology Methods Reveal the Basis for Selective Radioligand Binding to Alpha-Synuclein in MSA Tissue
Journal, issue, pagesTo Be Published
Publish dateApr 8, 2025 (structure data deposition date)
AuthorsSanchez JC / Perez RM / Borcik CG / Guarino DS / Dhavala DD / Baumgardt JK / Shaffer KD / Kotzbauer PT / Mach RH / Rienstra CM ...Sanchez JC / Perez RM / Borcik CG / Guarino DS / Dhavala DD / Baumgardt JK / Shaffer KD / Kotzbauer PT / Mach RH / Rienstra CM / Petersson EJ / Wright ER
External linksSearch PubMed
MethodsEM (helical sym.)
Resolution2.59 Å
Structure data

70093

9o4b

EMDB-70093, PDB-9o4b:
Cryo-EM structure of in-vitro alpha-synuclein fibril bound with Exemplar-6 PET-radioligand
Method: EM (helical sym.) / Resolution: 2.59 Å

Chemicals

PDB-1b9h:
CRYSTAL STRUCTURE OF 3-AMINO-5-HYDROXYBENZOIC ACID (AHBA) SYNTHASE

Source
  • homo sapiens (human)
KeywordsPROTEIN FIBRIL / alpha-synuclein / fibril / amyloid / STRUCTURAL PROTEIN

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