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| Title | Context-dependent translation inhibition as a novel oncology therapeutic modality |
|---|---|
| Journal, issue, pages | Nat Commun, Year 2026 |
| Publish date | Apr 7, 2025 (structure data deposition date) |
Authors | Sauer PV / Diamond PD / Holm M / Swanson-Swett CJ / Ferguson L / Bratset NM / Wienker GW / Sim JS / Adams HK / Kenner L ...Sauer PV / Diamond PD / Holm M / Swanson-Swett CJ / Ferguson L / Bratset NM / Wienker GW / Sim JS / Adams HK / Kenner L / Meyers M / Gygi D / Konst ZA / Bahmanyar SS / Hamann LG / Schuller AP |
External links | Nat Commun / Search PubMed |
| Methods | EM (single particle) |
| Resolution | 1.9 - 2.2 Å |
| Structure data | EMDB-70083, PDB-9o3v: EMDB-70084, PDB-9o3w: EMDB-70086, PDB-9o3y: |
| Chemicals | ![]() ChemComp-MG: ![]() ChemComp-K: ![]() ChemComp-SPD: ![]() ChemComp-PUT: ![]() ChemComp-TRS: ![]() ChemComp-ZN: ![]() ChemComp-HOH: ![]() PDB-1b75: ![]() PDB-1b76: |
| Source |
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Keywords | TRANSLATION / translation inhibitor / interdictor / ribosome / cryogenic-electron microscopy (cryo-EM) / ribotoxic stress response / cancer / MYC |
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homo sapiens (human)
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