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TitleStructural adaptation associated with signaling preference at the human GHRHR.
Journal, issue, pagesProtein Cell, Year 2026
Publish dateMar 19, 2026
AuthorsMing-Wei Wang / Kaini Hang / Yue Qiu / Xianyue Chen / Yanyan Chen / Shengtian Huang / Zhaotong Cong / Qingtong Zhou /
External linksProtein Cell / PubMed:41849435
MethodsEM (single particle)
Resolution2.88 - 3.04 Å
Structure data

69803
EMDB Unreleased entry

24tb

EMDB-69803, PDB-24tb:
Cryo-EM structure of the ligand-free (Apo) GHRHR-Gs complex
Method: EM (single particle) / Resolution: 3.03 Å

69804
EMDB Unreleased entry

24ti

EMDB-69804, PDB-24ti:
Cryo-EM structure of the PCO371-bound GHRHR-Gs complex
Method: EM (single particle) / Resolution: 2.88 Å

Chemicals

ChemComp-KHF:
PCO-371

Source
  • homo sapiens (human)
  • rattus norvegicus (Norway rat)
  • bos taurus (domestic cattle)
  • synthetic construct (others)
KeywordsMEMBRANE PROTEIN / GPCR / Complex / MEMBRANE PROTEIN/IMMUNE SYSTEM / GHRHR / PCO371 / MEMBRANE PROTEIN-IMMUNE SYSTEM complex

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