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Structure paper

TitleConsecutive catalytic steps of viral RNA polymerases and exonucleases suggest a way to overcome innate nucleotide analogue resistance
Journal, issue, pagesTo Be Published
Publish dateMar 2, 2026 (structure data deposition date)
AuthorsShannon A / Fattorini V / Sartre C / Chazot A / Moussa A / Sommadossi JP / Zhu YX / Wang MF / Shi H / Ferron F ...Shannon A / Fattorini V / Sartre C / Chazot A / Moussa A / Sommadossi JP / Zhu YX / Wang MF / Shi H / Ferron F / Alverez K / Canard B
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.39 Å
Structure data

69467

24ew

EMDB-69467, PDB-24ew:
SARS-CoV-2 polymerase with incorporated and pre-incorporated AT-9052-Sp
Method: EM (single particle) / Resolution: 2.39 Å

Chemicals

ChemComp-IF9:
[[(2R,3R,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methoxy-sulfanyl-phosphoryl] dihydrogen phosphate

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

PDB-1me1:
Chimeric hairpin with 2',5'-linked RNA loop and RNA stem

ChemComp-POP:
PYROPHOSPHATE 2-

Source
  • severe acute respiratory syndrome coronavirus 2
  • synthetic construct (others)
KeywordsRNA BINDING PROTEIN / RNA polymerase / RNA Exonuclease / coronavirus / arenavirus / stereospecificity

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