Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	A dual-receptor checkpoint primes enterovirus D68 for respiratory cell entry.
Journal, issue, pages	Nat Commun, Vol. 17, Issue 1, Year 2026
Publish date	Jul 23, 2026
Authors	Shengjian Liang / Haoran Guo / Zhili Xu / Zan Liu / Wanying Yang / Xiaoke Liu / Zhenyu Wei / Jichao Hou / Wei Huang / Wei Wang / Jiachen Li / Wendong Ma / Zhikang Deng / Haocong Qian / Yaxin Wang / Jialin Liu / Zihe Rao / Wei Wei / Zhiyong Lou /
PubMed Abstract	MFSD6 is a newly identified receptor that mediates the invasion of respiratory cells by enterovirus D68 (EV-D68), a non-polio enterovirus that causes severe respiratory disease and poliomyelitis-like ...MFSD6 is a newly identified receptor that mediates the invasion of respiratory cells by enterovirus D68 (EV-D68), a non-polio enterovirus that causes severe respiratory disease and poliomyelitis-like illness in children. Here, we report near-atomic-resolution cryo-electron microscopy (cryo-EM) structures of historical and contemporary AFM-associated EV-D68 strains, together with their complexes bound to the third extracellular loop of MFSD6 (MFSD6-L3). These structures uncover a previously unrecognized "binary gating switch" mechanism of virus-receptor engagement that differs from the reported model. In this mechanism, the N200-V208 segment of MFSD6, carrying a glycosylated Asn207, inserts into one capsomer, whereas the sialyl-Gal-terminated glycan of MFSD6 engages an adjacent capsomer. Neu5Ac binding induces conformational rearrangements that expel the pocket factor, destabilize the virion, and prime infection. Functional analyses further define the contributions of the receptor-contacting residues and glycans to viral attachment and entry. Together, our findings refine the molecular basis of EV-D68 recognition of MFSD6 and reveal a glycan-mediated dual-lock mechanism that may enhance receptor specificity, prevent premature uncoating, and ensure productive infection only upon engagement of the correct host receptor. These results provide broader insight into enterovirus tropism and establish a framework for structure-guided antiviral design.
External links	Nat Commun / PubMed:42637770 / PubMed Central
Methods	EM (single particle)
Resolution	2.0 - 3.21 Å
Structure data	65371 9vv0 EMDB-65371, PDB-9vv0: CryoEM structure of EV-D68 strain Fermon in complex with MFSD6-L3 Method: EM (single particle) / Resolution: 2.23 Å 65502 9w0d EMDB-65502, PDB-9w0d: CryoEM structure of procapsid in EV-D68:MFSD6-L3 Method: EM (single particle) / Resolution: 3.17 Å 65503 9w0e EMDB-65503, PDB-9w0e: CryoEM structure of B-particle in EV-D68:MFSD6-L3 Method: EM (single particle) / Resolution: 2.93 Å 65505 9w0i EMDB-65505, PDB-9w0i: CryoEM structure of EV-D68 strain Fermon in complex with MFSD6-L3-N207A Method: EM (single particle) / Resolution: 2.19 Å 65506 9w0j EMDB-65506, PDB-9w0j: CryoEM structure of EV-D68 strain Fermon in complex with MFSD6-L3-S209A Method: EM (single particle) / Resolution: 2.09 Å 65507 9w0k EMDB-65507, PDB-9w0k: CryoEM structure of EV-D68 strain Fermon in complex with MFSD6-R196-L226-NAtreat Method: EM (single particle) / Resolution: 2.29 Å 65590 9w34 EMDB-65590, PDB-9w34: CryoEM structure of EV-D68 strain Fermon procapsid Method: EM (single particle) / Resolution: 3.21 Å 65640 9w4o EMDB-65640, PDB-9w4o: CryoEM structure of EV-D68 strain Fermon mature virion Method: EM (single particle) / Resolution: 2.52 Å 65646 9w4y EMDB-65646, PDB-9w4y: CryoEM structure of EV-D68 strain Fermon in complex with MFSD6-R196-L226 Method: EM (single particle) / Resolution: 2.0 Å 68820 23ay EMDB-68820, PDB-23ay: CryoEM structure of EV-D68 US/MO/14-18947 mature virion Method: EM (single particle) / Resolution: 2.27 Å 68830 23bg EMDB-68830, PDB-23bg: CryoEM structure of EV-D68 US/MO/14-18947 in complex with MFSD6-L3 Method: EM (single particle) / Resolution: 2.47 Å 68851 23bx EMDB-68851, PDB-23bx: CryoEM structure of EV-D68 US/KY/14-18953 mature virion Method: EM (single particle) / Resolution: 2.62 Å 69155 23ps EMDB-69155, PDB-23ps: CryoEM structure of EV-D68 US/KY/14-18953 in complex with MFSD6-L3 Method: EM (single particle) / Resolution: 2.65 Å
Chemicals	ChemComp-SPH: SPHINGOSINE
Source	enterovirus d68 homo sapiens (human)
Keywords	VIRUS / EV-D68 / MFSD6 / VIRAL PROTEIN / procapsid / B-particle