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TitleRGS22 is a metazoa-specific radial spoke component required for coordinated ciliary beating.
Journal, issue, pagesNat Commun, Year 2026
Publish dateJun 24, 2026
AuthorsAnxuan Fang / Jiajun Luo / Haomang Xu / Ye-Jun Peng / Wei Xu / Huiwen Cao / Wei Li / Jialei Dai / Zhipeng Shi / Yong Wang / Xiao-Meng Li / Huijie Zhao / Miao Gui / Chao Yu / Xueliang Zhu / Qianting Zhang /
PubMed AbstractIn metazoan epithelia, arrays of motile cilia beat in a tissue-wide coordinated manner to drive unidirectional fluid flow. Whether radial spokes (RSs), which mediate mechano-signal transduction ...In metazoan epithelia, arrays of motile cilia beat in a tissue-wide coordinated manner to drive unidirectional fluid flow. Whether radial spokes (RSs), which mediate mechano-signal transduction between the central pair and axonemal dynein arms, acquire metazoa-specific subunit(s) in evolution to facilitate this function remains poorly known. Here we report that Gα-GTPase activating protein family member RGS22 is a metazoa-specific component of RS1/2 complexes. Mouse Rgs22-deficient motile cilia exhibit ultrastructural defects, including deformation of the RS1 and disorganization of outer dynein arms. These abnormalities correlate with impaired planar polarity, manifested as unsynchronized ciliary beating and disrupted rotational polarity of basal bodies across the ependyma. The motility deficits further lead to progressive ciliary loss and shortening, resulting in postnatal hydrocephalus. Together, our data identify RGS22 an animal-lineage RS1/2 component required for normal RS architecture and associated with tissue-level ciliary motility and coordination phenotypes.
External linksNat Commun / PubMed:42342706
MethodsEM (subtomogram averaging)
Resolution34.0 Å
Structure data

EMDB-68782: In situ cryo sub-tomogram average of the ciliary axoneme from Rgs22 knockout mouse ependymal progenitor cells
Method: EM (subtomogram averaging) / Resolution: 34.0 Å

Source
  • Mus musculus (house mouse)

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