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Structure paper

TitleSubtype-dependent arrestin engagement of the metabotropic glutamate receptors
Journal, issue, pagesTo be published
Publish dateJan 13, 2026 (structure data deposition date)
AuthorsLin S / Zhang C / Wei J / Yu J / Li S / Xu J / Su J / Chen K / Feng Y / Wang Z ...Lin S / Zhang C / Wei J / Yu J / Li S / Xu J / Su J / Chen K / Feng Y / Wang Z / Chu X / Yi C / Ma L / Han S / Zhang H / Shui W / Zhao Q / Wu B
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.0 - 3.9 Å
Structure data

EMDB-68364: Focused map of mGlu5 VFTs in mGlu5-beta-arrestin 1 complex
Method: EM (single particle) / Resolution: 3.0 Å

EMDB-68365: Focused map of mGlu5 CRD-TMDs in mGlu5-beta-arrestin 1 complex
Method: EM (single particle) / Resolution: 3.7 Å

EMDB-68366: Focused map of beta-arrestin 1 in mGlu5-beta-arrestin 1 complex
Method: EM (single particle) / Resolution: 3.2 Å

EMDB-68367: Overall map of mGlu5-beta-arrestin 1 complex
Method: EM (single particle) / Resolution: 3.5 Å

EMDB-68368: Overall map of mGlu7-beta-arrestin 1 complex
Method: EM (single particle) / Resolution: 3.9 Å

EMDB-68369: Focused map of mGlu7 TMDs-beta-arrestin 1 in mGlu7-beta-arrestin 1 complex
Method: EM (single particle) / Resolution: 3.4 Å

EMDB-68370: Focused map of mGlu7 ECDs in mGlu7-beta-arrestin 1 complex
Method: EM (single particle) / Resolution: 3.1 Å

68388

22jx

EMDB-68388, PDB-22jx:
Cryo-EM structure of the mGlu5-beta-arrestin 1 complex
Method: EM (single particle) / Resolution: 3.7 Å

68390

22jz

EMDB-68390, PDB-22jz:
Cryo-EM structure of the mGlu7-beta-arrestin 1 complex
Method: EM (single particle) / Resolution: 3.4 Å

Chemicals

ChemComp-GLU:
GLUTAMIC ACID

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CLR:
CHOLESTEROL

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsMEMBRANE PROTEIN/IMMUNE SYSTEM / GPCR / Metabotropic glutamate receptor / beta-arrestin / MEMBRANE PROTEIN / MEMBRANE PROTEIN-IMMUNE SYSTEM complex

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