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Structure paper

TitleOpen-state structure of veratridine-activated human Nav1.7 reveals the molecular choreography of fast inactivation
Journal, issue, pagesTo Be Published
Publish dateDec 24, 2025 (structure data deposition date)
AuthorsFan X / Chen J / Xue L / Wang H / Wu T / Huang X / Lu F / Jin X / Song C / Huang J / Yan N
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.7 Å
Structure data

67991

21tq

EMDB-67991, PDB-21tq:
The structure of Nav1.7 with veratridine standing near the IFM motif (site I)
Method: EM (single particle) / Resolution: 2.7 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-LPE:
1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE

PDB-1e26:
Design, Synthesis and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent.

ChemComp-Y01:
CHOLESTEROL HEMISUCCINATE

ChemComp-PCW:
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE / DOPC, phospholipid*YM

ChemComp-P3X:
(5E,17R,20S)-23-amino-20-hydroxy-14,20-dioxo-15,19,21-trioxa-20lambda~5~-phosphatricos-5-en-17-yl hexadecanoate

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Nav1.7 / voltage gated sodium channel / cryo-EM / veratridine / site I

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