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TitleLoss-of-function mutations in CCDC114 disrupt ODA docking and induce actin cytoskeletal remodeling in primary ciliary dyskinesia
Journal, issue, pagesTo Be Published
Publish dateMay 22, 2025 (structure data deposition date)
AuthorsChunxiao H / Ting L / Shuo Y / Yuan J / Feng Y / Zhangqi X / Junhua X / Lei W / Miao G / Shanshan X / Tianhua Z
External linksSearch PubMed
MethodsEM (single particle)
Resolution7.68 - 21.12 Å
Structure data

EMDB-64760: Cryo-EM density map of the 48-nm repeat of the human respiratory doublet microtubule
Method: EM (single particle) / Resolution: 7.68 Å

EMDB-64773: Cryo-EM density map of the 48-nm repeat of the CCDC114-mutant PCD patient respiratory doublet microtubule with c.705_706insGCAG mutation
Method: EM (single particle) / Resolution: 8.12 Å

EMDB-64774: Cryo-EM density map of the 96-nm repeat of the human respiratory doublet microtubule
Method: EM (single particle) / Resolution: 17.7 Å

EMDB-64775: Cryo-EM density map of the 48-nm repeat of the CCDC114-mutant PCD patient respiratory doublet microtubule with c.-41-2A>C mutation
Method: EM (single particle) / Resolution: 9.16 Å

EMDB-64779: Cyro-EM density map of the 96-nm repeat of the CCDC114-mutant PCD patient respiratory doublet microtubule with c.-41-2A>C mutation
Method: EM (single particle) / Resolution: 21.12 Å

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  • Homo sapiens (human)

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