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| Title | A C-based single-domain antibody broadly neutralizes SARS-CoV-2 and its variants through novel recognition of conserved regions in RBD |
|---|---|
| Journal, issue, pages | To Be Published |
| Publish date | May 15, 2024 (structure data deposition date) |
Authors | Wu B / Rao G / Zhang H / Yi Y / Zhao S / Qin Y / Li M / Chen L / Zhang Z / Mu J ...Wu B / Rao G / Zhang H / Yi Y / Zhao S / Qin Y / Li M / Chen L / Zhang Z / Mu J / Chiu S / Cao S / Gong R |
External links | Search PubMed |
| Methods | EM (single particle) |
| Resolution | 2.51 - 4.22 Å |
| Structure data | ![]() EMDB-60186: spike glycoprotein of SARS-CoV2 EG.5 ![]() EMDB-60187: Spike glycoprotein of SARS-CoV2 EG.5.1 ![]() EMDB-60188: Spike glycoprotein of SARS-CoV2 BA.1 ![]() EMDB-64592: The binding of a C-based single-domain antibody stabilizes spikes of SARS-CoV2 (JN.1) in all-RBD-up conformation ![]() EMDB-64593: The binding of a C-based single-domain antibody stabilizes spikes of SARS-CoV2 (Delta) in all-RBD-up conformation ![]() EMDB-64594: The binding of a C-based single-domain antibody stabilizes spikes of SARS-CoV2 (BA.5) in all-RBD-up conformation ![]() EMDB-64595: The binding of a C-based single-domain antibody stabilizes spikes of SARS-CoV2 (BA.2) in all-RBD-up conformation ![]() EMDB-64596: The binding of a C-based single-domain antibody stabilizes spikes of SARS-CoV2 (BA.1) in all-RBD-up conformation EMDB-64597, PDB-9uxs: ![]() EMDB-64598: Three RBD domains of the spike protein of SARS-CoV-2 JN.1 present all down conformation. ![]() EMDB-64599: Three RBD domains of the spike protein of SARS-CoV-2 JN.1 present two up and one down conformation ![]() EMDB-64600: Three RBD domains of the spike protein of SARS-CoV-2 JN.1 present one up and two down conformation |
| Source |
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Keywords | VIRAL PROTEIN/IMMUNE SYSTEM / SARS-CoV2 / RBD / Single-domain antibody / VIRAL PROTEIN-IMMUNE SYSTEM complex |
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homo sapiens (human)
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