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TitleRecognition of a phytocytokine by the DEPR1-SERK2 receptor complex confers multi-pathogen resistance in wheat.
Journal, issue, pagesMol Plant, Vol. 18, Issue 12, Page 1999-2017, Year 2025
Publish dateDec 1, 2025
AuthorsLijun Wang / Jun Zhao / Chuanchun Yin / Hongxu Li / Yanan Xiao / Cuicui Du / Zhaoxi Lu / Yongjian Zhang / Fangshuai Jia / Jiaxin Hao / Jinghui Yan / Yi Zhang / Jian Li / Xinhua Ding / Zhifu Han / Haitao Cui / Jijie Chai / Xingwang Deng / Cheng Chi / Shuguo Hou /
PubMed AbstractThe recognition of plant-derived immunogenic peptides, known as phytocytokines (PCKs), by cell surface receptors triggers immune signaling pathways that bolster basal plant defense against pathogens. ...The recognition of plant-derived immunogenic peptides, known as phytocytokines (PCKs), by cell surface receptors triggers immune signaling pathways that bolster basal plant defense against pathogens. However, little is known about the molecular mechanisms that underlie PCK-mediated immune regulation in wheat. In this study, we identified a wheat PCK, delta-like PCK (DEP), that robustly activates immune responses and confers multi-pathogen resistance. DEP is perceived by the leucine-rich repeat (LRR) receptor kinases (RKs) DEP RECEPTOR 1 (DEPR1) and SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 2 (SERK2) and triggers DEPR1- and SERK2-dependent immune signaling. Cryogenic electron microscopy structural analysis revealed that DEP2 binds to the extracellular LRR domain of DEPR1 and recruits SERK2 through a disulfide-bond-stabilized loop to promote DEPR1-SERK2 heterodimerization. Furthermore, we showed that the DEP2-DEPR1-SERK2 module confers wheat resistance to Xanthomonas translucens, Fusarium graminearum, and Fusarium pseudograminearum. We also demonstrated that this module enhances wheat resistance to X. translucens by antagonizing abscisic acid signaling. Collectively, our study reveals a novel PCK-mediated immune signaling pathway and suggests a promising strategy for engineering multi-pathogen resistance in wheat.
External linksMol Plant / PubMed:41076557
MethodsEM (single particle)
Resolution3.33 Å
Structure data

64376

9uob

EMDB-64376, PDB-9uob:
Plant-TaNNS
Method: EM (single particle) / Resolution: 3.33 Å

Source
  • triticum aestivum (bread wheat)
KeywordsPLANT PROTEIN / Complex / Immunity

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