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TitleUnique Gluing Effect of ASXL1 K351 Monoubiquitination Stimulates PR-DUB-Mediated Nucleosomal H2AK119Ub Deubiquitination
Journal, issue, pagesBiorxiv, Year 2025
Publish dateMar 21, 2025 (structure data deposition date)
AuthorsZhang T / Zheng J / Tong Z / Deng Z / He Z / Wu X / Wang M / Du Y / Xu Z / Tao S ...Zhang T / Zheng J / Tong Z / Deng Z / He Z / Wu X / Wang M / Du Y / Xu Z / Tao S / Tian X / Deng H / Pan M / Ai H / Liu L
External linksBiorxiv / Search PubMed
MethodsEM (single particle)
Resolution3.12 - 3.27 Å
Structure data

63884

9u5u

EMDB-63884, PDB-9u5u:
The 1:1 cryo-EM structure of BAP1/ASXL1-K351Ub in complex with H2AK119Ub nucleosome
Method: EM (single particle) / Resolution: 3.12 Å

EMDB-63885: The 2:1 map of BAP1/ASXL1-K351Ub in complex with H2AK119Ub nucleosome
Method: EM (single particle) / Resolution: 3.27 Å

Source
  • homo sapiens (human)
KeywordsNUCLEAR PROTEIN/DNA / PR-DUB / nucleosome / H2AK119Ub / BAP1 / BAP1/ASXL1 / ASXL1 K351Ub The 2:1 complex of BAP1-ASXL1-K351Ub and H2AK119Ub nucleosome / NUCLEAR PROTEIN-DNA complex

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