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TitlepH-Dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205.
Journal, issue, pagesProc Natl Acad Sci U S A, Vol. 112, Issue 23, Page 7237-7242, Year 2015
Publish dateJun 9, 2015
AuthorsLongxing Cao / Xiangyi Shi / Haishuang Chang / Qinfen Zhang / Yongning He /
PubMed AbstractDendritic cells play important roles in regulating innate and adaptive immune responses. DEC205 (CD205) is one of the major endocytotic receptors on dendritic cells and has been widely used for ...Dendritic cells play important roles in regulating innate and adaptive immune responses. DEC205 (CD205) is one of the major endocytotic receptors on dendritic cells and has been widely used for vaccine generation against viruses and tumors. However, little is known about its structure and functional mechanism. Here we determine the structure of the human DEC205 ectodomain by cryoelectron microscopy. The structure shows that the 12 extracellular domains form a compact double ring-shaped conformation at acidic pH and become extended at basic pH. Biochemical data indicate that the pH-dependent conformational change of DEC205 is correlated with ligand binding and release. DEC205 only binds to apoptotic and necrotic cells at acidic pH, whereas live cells cannot be recognized by DEC205 at either acidic or basic conditions. These results suggest that DEC205 is an immune receptor that recognizes apoptotic and necrotic cells specifically through a pH-dependent mechanism.
External linksProc Natl Acad Sci U S A / PubMed:26039988 / PubMed Central
MethodsEM (single particle)
Resolution14.6 Å
Structure data

EMDB-6333:
Structure of DEC205 at acidic pH
Method: EM (single particle) / Resolution: 14.6 Å

Source
  • Homo sapiens (human)

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