EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structural decoding of reversible covalent linkage of odorants in human olfactory receptor OR6A2.
ジャーナル・号・ページ	Cell, Vol. 189, Issue 5, Page 1451-1464.e27, Year 2026
掲載日	2026年3月5日
著者	Tian Wang / Yiran Wu / Ling Wang / Shanshan Li / Fei Zhao / Lijie Wu / Yue Liu / Jingzi Qin / Qiwen Tan / Junlin Liu / Liting Zeng / Yilin Chen / Shenyuan Gao / Wenqing Shui / Suwen Zhao / Tian Hua / Zhi-Jie Liu /
PubMed 要旨	Olfactory receptors (ORs) are a diverse superfamily of G protein-coupled receptors responsible for odor detection that are also implicated in non-olfactory physiological functions. OR6A2, a class II ...Olfactory receptors (ORs) are a diverse superfamily of G protein-coupled receptors responsible for odor detection that are also implicated in non-olfactory physiological functions. OR6A2, a class II OR, selectively senses medium-chain aldehydes and belongs to a cluster of ORs genetically associated with the "soapy" perception of cilantro. It also modulates macrophage-mediated inflammatory responses. Structural studies of ORs have long been challenging. Using a back-mutation strategy, we engineered a functional OR6A2 variant (bmOR6A2) from a consensus OR6 (consOR6). Structures of bmOR6A2 in complex with aldehydes reveal a novel ligand-recognition mechanism involving a reversible Schiff base linkage with residue K, validated by mass spectrometry. By integrating structures of consOR6, molecular dynamics simulations, and functional assays, we identified a conserved DYY triad critical for activation in class II ORs. These findings establish a practical strategy for decoding odorant recognition, offering new insights into olfaction signaling and applications in fragrance and therapeutic development.
リンク	Cell / PubMed:41570822
手法	EM (単粒子)
解像度	2.54 - 3.33 Å
構造データ	63007 9ldv EMDB-63007, PDB-9ldv: Consensus olfactory receptor consOR6 in complex with mini-Golf trimeric protein 手法: EM (単粒子) / 解像度: 2.78 Å 63008 9ldw EMDB-63008, PDB-9ldw: Consensus olfactory receptor consOR6 bound to alpha-hexyl cinnamaldehyde and in complex with mini-Golf trimeric protein 手法: EM (単粒子) / 解像度: 2.62 Å 63009 9ldx EMDB-63009, PDB-9ldx: Consensus olfactory receptor consOR6 in complex with mini-Golf trimeric protein 手法: EM (単粒子) / 解像度: 2.83 Å 63010 9ldz EMDB-63010, PDB-9ldz: Consensus olfactory receptor consOR6 in complex with Gs trimeric protein 手法: EM (単粒子) / 解像度: 3.17 Å 63011 9le0 EMDB-63011, PDB-9le0: Consensus olfactory receptor bmOR6A2 in complex with mini-Golf trimeric protein 手法: EM (単粒子) / 解像度: 2.54 Å 63012 9le1 EMDB-63012, PDB-9le1: Consensus olfactory receptor bmOR6A2 in complex with mini-Golf trimeric protein 手法: EM (単粒子) / 解像度: 3.3 Å 63013 9le2 EMDB-63013, PDB-9le2: Consensus olfactory receptor bmOR6A2 in complex with mini-Golf trimeric protein 手法: EM (単粒子) / 解像度: 3.33 Å
化合物	PDB-1ejq: SOLUTION STRUCTURE OF THE SYNDECAN-4 WHOLE CYTOPLASMIC DOMAIN IN THE PRESENCE OF PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE ChemComp-CLR: CHOLESTEROL PDB-1ejg: CRAMBIN AT ULTRA-HIGH RESOLUTION: VALENCE ELECTRON DENSITY. ChemComp-BZQ: DIPHENYLMETHANONE ChemComp-OYA: OCTANAL PDB-1ejh: EIF4E/EIF4G PEPTIDE/7-METHYL-GDP
由来	homo sapiens (ヒト) synthetic construct (人工物) mus musculoides (ネズミ)
キーワード	MEMBRANE PROTEIN/IMMUNE SYSTEM / complex / MEMBRANE PROTEIN / GPCR / MEMBRANE PROTEIN-IMMUNE SYSTEM complex