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TitleStructural insights into the distinct ligand recognition and signaling of the chemerin receptors CMKLR1 and GPR1.
Journal, issue, pagesProtein Cell, Vol. 16, Issue 5, Page 381-385, Year 2025
Publish dateMay 28, 2025
AuthorsXiaowen Lin / Lechen Zhao / Heng Cai / Xiaohua Chang / Yuxuan Tang / Tianyu Luo / Mengdan Wu / Cuiying Yi / Limin Ma / Xiaojing Chu / Shuo Han / Qiang Zhao / Beili Wu / Maozhou He / Ya Zhu /
External linksProtein Cell / PubMed:39752296 / PubMed Central
MethodsEM (single particle)
Resolution2.7 - 3.9 Å
Structure data

EMDB-62730: Consensus map of the chemokine-like receptor 1 (CMKLR1) in complex with chemerin and Gi1
Method: EM (single particle) / Resolution: 3.4 Å

EMDB-62732: Focused refinement in chemerin and receptor regions of the chemokine-like receptor 1 (CMKLR1) in complex with chemerin and Gi1
Method: EM (single particle) / Resolution: 3.47 Å

EMDB-62792: Focused refinement in G protein region of the chemokine-like receptor 1 (CMKLR1) in complex with chemerin and Gi1
Method: EM (single particle) / Resolution: 2.7 Å

EMDB-62793, PDB-9l3w:
Cryo-EM structure of the chemokine-like receptor 1 in complex with chemerin and Gi1
Method: EM (single particle) / Resolution: 3.5 Å

EMDB-62794: Consensus map of the G-protein coupled receptor 1 (GPR1) in complex with chemerin and Gi1chemerin-GPR1-Gi complex
Method: EM (single particle) / Resolution: 3.6 Å

EMDB-62795: Focused refinement in chemerin and receptor regions of the G-protein coupled receptor 1 (GPR1) in complex with chemerin and Gi1
Method: EM (single particle) / Resolution: 3.6 Å

EMDB-62796: Focused refinement in G protein region of the G-protein coupled receptor 1 (GPR1) in complex with chemerin and Gi1
Method: EM (single particle) / Resolution: 2.8 Å

EMDB-62798, PDB-9l3y:
Cryo-EM structure of the G-protein coupled receptor 1 (GPR1) in complex with chemerin and Gi1
Method: EM (single particle) / Resolution: 3.6 Å

EMDB-62799, PDB-9l3z:
Cryo-EM structure of the inactive chemokine-like receptor 1 (CMKLR1)
Method: EM (single particle) / Resolution: 3.9 Å

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
  • escherichia coli (E. coli)
KeywordsMEMBRANE PROTEIN / GPCR / CMKLR1 / GPR1 / MEMBRANE PROTEIN/IMMUNE SYSTEM / MEMBRANE PROTEIN-IMMUNE SYSTEM complex

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