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TitleCXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting
Journal, issue, pagesNat Commun, Vol. 17, Page 101, Year 2026
Publish dateNov 15, 2024 (structure data deposition date)
AuthorsItoh-Nakadai A / Liang M / Shindo M / Bibi C / Tomizawa-Murasawa M / Fujiki S / Kaneko A / Kanamaru E / Hashimoto M / Kajita H ...Itoh-Nakadai A / Liang M / Shindo M / Bibi C / Tomizawa-Murasawa M / Fujiki S / Kaneko A / Kanamaru E / Hashimoto M / Kajita H / Ando Y / Kojima M / Moody J / Iwasaki M / Takagi S / Nakagawa R / Agrawal S / Amitani-Iijima H / Sato K / Sorimachi Y / Suzuki N / Fukami T / Hanada K / Morita S / Katsura K / Matsumoto T / Kobayashi M / Kato M / Negishi Y / Shirouzu M / Najima Y / Takubo K / Hon CC / Uchida N / Taniguchi S / Momozawa Y / Carninci P / Shultz LD / Saito Y / de Hoon M / Shin JW / Ishikawa F
External linksNat Commun / Search PubMed
MethodsEM (single particle)
Resolution2.97 Å
Structure data

62427

9kmc

EMDB-62427, PDB-9kmc:
Cryo-EM structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 and anti-CD25 Fab S417
Method: EM (single particle) / Resolution: 2.97 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • sythetic construct (others)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / CYTOKINE

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